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1015  structures 9110  species 0  interactions 233837  sequences 3012  architectures

Clan: 4Fe-4S (CL0344)


4Fe-4S ferredoxins Add an annotation

Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.

This clan contains 29 families and the total number of domains in the clan is 233837. The clan was built by A Bateman.


This clan contains the following 29 member families:

ETF_QO Fer4 Fer4_10 Fer4_11 Fer4_12 Fer4_13 Fer4_14 Fer4_15 Fer4_16 Fer4_17 Fer4_18 Fer4_19 Fer4_2 Fer4_20 Fer4_21 Fer4_22 Fer4_23 Fer4_24 Fer4_3 Fer4_4 Fer4_5 Fer4_6 Fer4_7 Fer4_8 Fer4_9 FeS Molybdop_Fe4S4 Nitr_red_alph_N RLI

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Fer4 (PF00037) 31425 (13.4%) View
Fer4_7 (PF12838) 28389 (12.1%) View
Fer4_12 (PF13353) 21811 (9.3%) View
Fer4_8 (PF13183) 18901 (8.1%) View
Molybdop_Fe4S4 (PF04879) 16635 (7.1%) View
Fer4_14 (PF13394) 15720 (6.7%) View
Fer4_20 (PF14691) 13919 (6.0%) View
Fer4_5 (PF12801) 12085 (5.2%) View
Fer4_11 (PF13247) 10338 (4.4%) View
Fer4_17 (PF13534) 8791 (3.8%) View
Fer4_9 (PF13187) 8487 (3.6%) View
Fer4_16 (PF13484) 6366 (2.7%) View
Fer4_21 (PF14697) 5814 (2.5%) View
Fer4_13 (PF13370) 5494 (2.3%) View
ETF_QO (PF05187) 4882 (2.1%) View
Pfam family Num. domains Alignment
FeS (PF04060) 4422 (1.9%) View
Fer4_4 (PF12800) 4402 (1.9%) View
RLI (PF04068) 3568 (1.5%) View
Fer4_15 (PF13459) 3458 (1.5%) View
Fer4_18 (PF13746) 3263 (1.4%) View
Fer4_6 (PF12837) 1695 (0.7%) View
Fer4_19 (PF06902) 1088 (0.5%) View
Fer4_22 (PF17179) 1013 (0.4%) View
Nitr_red_alph_N (PF14710) 877 (0.4%) View
Fer4_24 (PF18109) 573 (0.2%) View
Fer4_3 (PF12798) 203 (0.1%) View
Fer4_23 (PF18009) 142 (0.1%) View
Fer4_2 (PF12797) 76 (0.0%) View
Fer4_10 (PF13237) 0 (0.0%) View
Total: 29 Total: 233837 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...