Summary
4-helical cytokine superfamily
Cytokines are regulatory peptides that can be produced by various cells for communicating and orchestrating the large multicellular system. Cytokines are key mediators of hematopoiesis, immunity, allergy, inflammation, tissue remodeling, angiogenesis, and embryonic development [2]. This superfamily includes both the long and short chain helical cytokines.
This clan contains 29 families and the total number of domains in the clan is 12092. The clan was built by A Bateman.
Literature references
- Hill EE, Morea V, Chothia C; , J Mol Biol 2002;322:205-233.: Sequence conservation in families whose members have little or no sequence similarity: the four-helical cytokines and cytochromes. PUBMED:12215425 EPMC:12215425
- Ouyang S, He F; , J Mol Evol 2003;56:131-136.: Phylogeny of a growth hormone-like cytokine superfamily based upon 3D structure. PUBMED:12574859 EPMC:12574859
Members
This clan contains the following 29 member families:
CNTF CSF-1 EPO_TPO Flt3_lig GCSF GM_CSF Hormone_1 IFN-gamma IL10 IL11 IL12 IL13 IL15 IL2 IL22 IL23 IL28A IL3 IL34 IL4 IL5 IL6 IL7 Interferon Leptin LIF_OSM PRF SCF TSLPExternal database links
| CATH: | 1.20.120.210 1.20.120.200 |
| SCOP: | 47266 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
| Pfam family | Num. domains | Alignment |
|---|---|---|
| Interferon (PF00143) | 2077 (17.2%) | View |
| Hormone_1 (PF00103) | 1909 (15.8%) | View |
| IL10 (PF00726) | 750 (6.2%) | View |
| EPO_TPO (PF00758) | 666 (5.5%) | View |
| SCF (PF02404) | 584 (4.8%) | View |
| IL15 (PF02372) | 578 (4.8%) | View |
| IL28A (PF15177) | 428 (3.5%) | View |
| CSF-1 (PF05337) | 400 (3.3%) | View |
| LIF_OSM (PF01291) | 361 (3.0%) | View |
| IL7 (PF01415) | 353 (2.9%) | View |
| IL6 (PF00489) | 353 (2.9%) | View |
| IL12 (PF03039) | 337 (2.8%) | View |
| PRF (PF06875) | 330 (2.7%) | View |
| IL34 (PF15036) | 322 (2.7%) | View |
| IL11 (PF07400) | 291 (2.4%) | View |
| continued | ||
| Pfam family | Num. domains | Alignment |
|---|---|---|
| Flt3_lig (PF02947) | 258 (2.1%) | View |
| CNTF (PF01110) | 248 (2.1%) | View |
| IL22 (PF14565) | 240 (2.0%) | View |
| IFN-gamma (PF00714) | 230 (1.9%) | View |
| GCSF (PF16647) | 209 (1.7%) | View |
| Leptin (PF02024) | 206 (1.7%) | View |
| IL4 (PF00727) | 195 (1.6%) | View |
| IL5 (PF02025) | 142 (1.2%) | View |
| IL23 (PF16649) | 128 (1.1%) | View |
| IL2 (PF00715) | 122 (1.0%) | View |
| IL13 (PF03487) | 113 (0.9%) | View |
| GM_CSF (PF01109) | 104 (0.9%) | View |
| TSLP (PF15216) | 85 (0.7%) | View |
| IL3 (PF02059) | 73 (0.6%) | View |
| Total: 29 | Total: 12092 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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