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82  structures 8968  species 0  interactions 179413  sequences 1294  architectures

Clan: ABC-2 (CL0181)


ABC-2-transporter-like clan Add an annotation

These families are similar to the ABC-2 transporter subfamily, as described in [1] (Pfam:PF01061). Members of this family are involved in drug transport and resistance. CcmB protein family (Pfam:PF03379) members are also transporters; they are required for haem export into the periplasm [2].

This clan contains 17 families and the total number of domains in the clan is 179413. The clan was built by M Fenech.

Literature references

  1. Reizer J, Reizer A, Saier MH Jr; , Protein Sci 1992;1:1326-1332.: A new subfamily of bacterial ABC-type transport systems catalyzing export of drugs and carbohydrates. PUBMED:1303751 EPMC:1303751
  2. Thony-Meyer L, Fischer F, Kunzler P, Ritz D, Hennecke H; , J Bacteriol 1995;177:4321-4326.: Escherichia coli genes required for cytochrome c maturation. PUBMED:7635817 EPMC:7635817


This clan contains the following 17 member families:

12TM_1 ABC2_membrane ABC2_membrane_2 ABC2_membrane_3 ABC2_membrane_4 ABC2_membrane_5 ABC2_membrane_6 ABC2_membrane_7 ABC_export ABC_tran_2 CcmB DUF2705 DUF3526 DUF3533 DUF6198 PDR_CDR YitT_membrane

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ABC2_membrane (PF01061) 70903 (39.5%) View
ABC2_membrane_3 (PF12698) 36270 (20.2%) View
ABC2_membrane_7 (PF19055) 25970 (14.5%) View
ABC2_membrane_2 (PF12679) 12558 (7.0%) View
YitT_membrane (PF02588) 8965 (5.0%) View
PDR_CDR (PF06422) 6765 (3.8%) View
ABC2_membrane_4 (PF12730) 4984 (2.8%) View
ABC2_membrane_6 (PF06182) 4312 (2.4%) View
CcmB (PF03379) 3060 (1.7%) View
DUF3533 (PF12051) 1848 (1.0%) View
ABC2_membrane_5 (PF13346) 1696 (0.9%) View
DUF6198 (PF19700) 736 (0.4%) View
DUF3526 (PF12040) 695 (0.4%) View
ABC_tran_2 (PF16949) 368 (0.2%) View
ABC_export (PF16962) 204 (0.1%) View
12TM_1 (PF09847) 44 (0.0%) View
DUF2705 (PF10920) 35 (0.0%) View
Total: 17 Total: 179413 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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