Summary
Alpha/Beta hydrolase fold
This catalytic domain is found in a very wide range of enzymes.
This clan contains 75 families and the total number of domains in the clan is 643854. The clan was built by A Bateman.
Literature references
- Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM, Harel M, Remington SJ, Silman I, Schrag J, Sussman JL, Verschueren KHG, Goldman A; , Protein Eng 1992;5:197-211.: The alpha/beta hydrolase fold PUBMED:1409539 EPMC:1409539
Members
This clan contains the following 75 member families:
3HBOH ABHD18 Abhydro_lipase Abhydrolase_1 Abhydrolase_10 Abhydrolase_11 Abhydrolase_2 Abhydrolase_3 Abhydrolase_4 Abhydrolase_5 Abhydrolase_6 Abhydrolase_7 Abhydrolase_8 Abhydrolase_9 Acyl_transf_2 Asp2 AXE1 BAAT_C BD-FAE Chlorophyllase Chlorophyllase2 COesterase Cutinase DLH DUF1057 DUF1350 DUF1400 DUF1749 DUF2235 DUF2920 DUF3089 DUF3141 DUF3530 DUF452 DUF6351 DUF676 DUF726 DUF818 DUF829 DUF900 DUF915 EHN Esterase Esterase_PHB FrsA-like FSH1 Hydrolase_4 LCAT LIDHydrolase LIP Lipase Lipase3_N Lipase_2 Lipase_3 Mbeg1-like Ndr PAE PAF-AH_p_II Palm_thioest PE-PPE Peptidase_S10 Peptidase_S15 Peptidase_S28 Peptidase_S37 Peptidase_S9 PGAP1 PhaC_N PHB_depo_C PhoPQ_related Say1_Mug180 Ser_hydrolase Tannase Thioesterase UPF0227 VirJExternal database links
CATH: | 3.40.50.1820 |
SCOP: | 53474 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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