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305  structures 1587  species 0  interactions 54406  sequences 577  architectures

Clan: ADF (CL0092)


Actin depolymerizing Factor Add an annotation

For motile cells such as Amoeba to move, there must be the rapid recycling of their actin cytoskeleton to enable a dynamic change in their shape. Gelsolin (PFAM:PF00626) and Cofilin (PFAM:PF00241) are two key domain families in this process. Both of these domain are structural and functional similar [1,2]. In particular, the beta sheet found at the core of the domain is structurally well conserved, with the helices that surround this sheet less conserved[2].

This clan contains 2 families and the total number of domains in the clan is 54406. The clan was built by RD Finn.

Literature references

  1. Southwick FS; , Proc Natl Acad Sci U S A 2000;97:6936-6938.: Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells. PUBMED:10860951 EPMC:10860951
  2. Hatanaka H, Ogura K, Moriyama K, Ichikawa S, Yahara I, Inagaki F; , Cell 1996;85:1047-1055.: Tertiary structure of destrin and structural similarity between two actin-regulating protein families. PUBMED:8674111 EPMC:8674111


This clan contains the following 2 member families:

Cofilin_ADF Gelsolin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Gelsolin (PF00626) 40966 (75.3%) View
Cofilin_ADF (PF00241) 13440 (24.7%) View
Total: 2 Total: 54406 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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