Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1201  structures 6212  species 0  interactions 29514  sequences 1344  architectures

Clan: ADP-ribosyl (CL0084)


ADP-ribosylation Superfamily Add an annotation

The members of this clan all represent ADP-ribosylating catalytic domains. The structurally conserved regions are located at the NAD binding region [1]. According to SCOP, the ADP-ribosylation domain is thought to have an "unusual fold".

This clan contains 23 families and the total number of domains in the clan is 29514. The clan was built by RD Finn.

Literature references

  1. Ame JC, Spenlehauer C, de Murcia G; , Bioessays 2004;26:882-893.: The PARP superfamily. PUBMED:15273990 EPMC:15273990


This clan contains the following 23 member families:

ADPrib_exo_Tox ADPRTs_Tse2 Anthrax-tox_M Arr-ms ART ART-PolyVal AvrPphF-ORF-2 DarT Diphtheria_C Dot_icm_IcmQ DUF2441 DUF3990 DUF952 Enterotoxin_a Exotox-A_cataly NADase_NGA PARP Pertussis_S1 PTS_2-RNA RES RolB_RolC SidE_mART TNT

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PARP (PF00644) 12749 (43.2%) View
RES (PF08808) 3909 (13.2%) View
PTS_2-RNA (PF01885) 3410 (11.6%) View
DUF952 (PF06108) 2795 (9.5%) View
ART (PF01129) 2174 (7.4%) View
TNT (PF14021) 921 (3.1%) View
Arr-ms (PF12120) 694 (2.4%) View
DUF3990 (PF13151) 681 (2.3%) View
DarT (PF14487) 628 (2.1%) View
ADPrib_exo_Tox (PF03496) 614 (2.1%) View
Enterotoxin_a (PF01375) 478 (1.6%) View
ART-PolyVal (PF18760) 118 (0.4%) View
Pfam family Num. domains Alignment
DUF2441 (PF10386) 90 (0.3%) View
Pertussis_S1 (PF02917) 87 (0.3%) View
RolB_RolC (PF02027) 53 (0.2%) View
ADPRTs_Tse2 (PF18648) 37 (0.1%) View
Dot_icm_IcmQ (PF09475) 33 (0.1%) View
NADase_NGA (PF07461) 14 (0.0%) View
Exotox-A_cataly (PF09009) 9 (0.0%) View
AvrPphF-ORF-2 (PF09143) 9 (0.0%) View
Diphtheria_C (PF02763) 6 (0.0%) View
SidE_mART (PF19048) 4 (0.0%) View
Anthrax-tox_M (PF09156) 1 (0.0%) View
Total: 23 Total: 29514 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...