Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
57  structures 3476  species 0  interactions 13061  sequences 201  architectures

Clan: APCOP-app_sub (CL0545)


Clathrin (AP) and COPI appendage platform subdomain Add an annotation

This superfamily is characterised by subdomains from the clathrin and coatomer appendages. The superfamily possesses a single protein/protein interaction site that in yeast binds to the ARFGAP Glo3p, and in mammalian gamma-COP binds to a Glo3p orthologue, ARFGAP2 [1].

This clan contains 8 families and the total number of domains in the clan is 13061. The clan was built by P Coggill.

Literature references

  1. Watson PJ, Frigerio G, Collins BM, Duden R, Owen DJ; , Traffic. 2004;5:79-88.: Gamma-COP appendage domain - structure and function. PUBMED:14690497 EPMC:14690497


This clan contains the following 8 member families:

Alpha_adaptin_C AP4E_app_platf B2-adapt-app_C Coatomer_b_Cpla Coatomer_g_Cpla DUF1499 DUF3630 PHA_gran_rgn

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
B2-adapt-app_C (PF09066) 2841 (21.8%) View
Alpha_adaptin_C (PF02296) 2340 (17.9%) View
DUF1499 (PF07386) 2303 (17.6%) View
Coatomer_g_Cpla (PF16381) 2168 (16.6%) View
Coatomer_b_Cpla (PF14806) 2006 (15.4%) View
PHA_gran_rgn (PF09650) 832 (6.4%) View
AP4E_app_platf (PF14807) 418 (3.2%) View
DUF3630 (PF12305) 153 (1.2%) View
Total: 8 Total: 13061 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...