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982  structures 9039  species 0  interactions 170380  sequences 1604  architectures

Clan: ATP-grasp (CL0179)


ATP-grasp superfamily Add an annotation

The ATP-grasp domain is found in a wide variety of carboxylate-amine/thiol ligases [1]. It is composed of two subdomains, with ATP being bound in the cleft between the two.

This clan contains 26 families and the total number of domains in the clan is 170380. The clan was built by A Bateman.

Literature references

  1. Galperin MY, Koonin EV; , Protein Sci 1997;6:2639-2643.: A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity. PUBMED:9416615 EPMC:9416615


This clan contains the following 26 member families:

ATP-grasp ATP-grasp_2 ATP-grasp_3 ATP-grasp_4 ATP-grasp_5 ATP-grasp_6 ATPgrasp_ST ATPgrasp_Ter ATPgrasp_TupA ATPgrasp_YheCD CP_ATPgrasp_1 CP_ATPgrasp_2 CPSase_L_D2 D123 Dala_Dala_lig_C DUF1297 GARS_A GSH-S_ATP GSP_synth Ins134_P3_kin PPDK_N R2K_2 R2K_3 RimK Synapsin_C TTL

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CPSase_L_D2 (PF02786) 54254 (31.8%) View
PPDK_N (PF01326) 17188 (10.1%) View
Dala_Dala_lig_C (PF07478) 11914 (7.0%) View
ATP-grasp_2 (PF08442) 11471 (6.7%) View
TTL (PF03133) 11376 (6.7%) View
GARS_A (PF01071) 10062 (5.9%) View
ATP-grasp (PF02222) 9632 (5.7%) View
RimK (PF08443) 7891 (4.6%) View
ATP-grasp_5 (PF13549) 6324 (3.7%) View
CP_ATPgrasp_2 (PF14403) 4502 (2.6%) View
ATP-grasp_4 (PF13535) 4005 (2.4%) View
GSH-S_ATP (PF02955) 3697 (2.2%) View
ATPgrasp_YheCD (PF14398) 2599 (1.5%) View
Ins134_P3_kin (PF05770) 2299 (1.3%) View
Pfam family Num. domains Alignment
ATP-grasp_3 (PF02655) 2282 (1.3%) View
GSP_synth (PF03738) 2151 (1.3%) View
D123 (PF07065) 2011 (1.2%) View
Synapsin_C (PF02750) 1682 (1.0%) View
ATPgrasp_Ter (PF15632) 1365 (0.8%) View
ATPgrasp_ST (PF14397) 1291 (0.8%) View
ATPgrasp_TupA (PF14305) 914 (0.5%) View
R2K_3 (PF14243) 473 (0.3%) View
ATP-grasp_6 (PF18419) 307 (0.2%) View
R2K_2 (PF18299) 252 (0.1%) View
DUF1297 (PF06973) 238 (0.1%) View
CP_ATPgrasp_1 (PF04174) 200 (0.1%) View
Total: 26 Total: 170380 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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