Summary
Alkaline phosphatase-like
The members of this clan all share a common structure of their catalytic domains, which contain conserved metal binding residues [1].
This clan contains 10 families and the total number of domains in the clan is 120656. The clan was built by RD Finn.
Literature references
- Galperin MY, Jedrzejas MJ; , Proteins 2001;45:318-324.: Conserved core structure and active site residues in alkaline phosphatase superfamily enzymes. PUBMED:11746679 EPMC:11746679
Members
This clan contains the following 10 member families:
Alk_phosphatase DUF1501 DUF229 DUF4976 Metalloenzyme PglZ Phosphodiest Phosphoesterase Sulfatase Sulfatase_CExternal database links
CATH: | 3.40.720.10 |
SCOP: | 53649 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
Sulfatase (PF00884) | 51791 (42.9%) | View |
Phosphodiest (PF01663) | 20702 (17.2%) | View |
Metalloenzyme (PF01676) | 10873 (9.0%) | View |
Alk_phosphatase (PF00245) | 8058 (6.7%) | View |
DUF1501 (PF07394) | 7851 (6.5%) | View |
Phosphoesterase (PF04185) | 7673 (6.4%) | View |
DUF4976 (PF16347) | 6118 (5.1%) | View |
Sulfatase_C (PF14707) | 3363 (2.8%) | View |
DUF229 (PF02995) | 2483 (2.1%) | View |
PglZ (PF08665) | 1744 (1.4%) | View |
Total: 10 | Total: 120656 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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