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1545  structures 9202  species 0  interactions 212063  sequences 1361  architectures

Clan: Amidohydrolase (CL0034)


Amidohydrolase superfamily Add an annotation

This family includes a large family of metal dependent amidohydrolase enzymes [1].

This clan contains 17 families and the total number of domains in the clan is 212063. The clan was built by A Bateman.

Literature references

  1. Holm L, Sander C; , Proteins 1997;28:72-82.: An evolutionary treasure: unification of a broad set of amidohydrolases related to urease. PUBMED:9144792 EPMC:9144792


This clan contains the following 17 member families:

A_deaminase Amidohydro_1 Amidohydro_2 Amidohydro_3 AMP_deaminase CpsB_CapC DHOase DUF3604 DUF6282 Peptidase_M19 PHP PHP_C PTE RNase_P_p30 TatD_DNase Urease_alpha UxaC

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Amidohydro_1 (PF01979) 75840 (35.8%) View
PHP (PF02811) 27454 (12.9%) View
Amidohydro_2 (PF04909) 26475 (12.5%) View
Amidohydro_3 (PF07969) 21673 (10.2%) View
TatD_DNase (PF01026) 17699 (8.3%) View
A_deaminase (PF00962) 12213 (5.8%) View
Peptidase_M19 (PF01244) 8559 (4.0%) View
AMP_deaminase (PF19326) 5026 (2.4%) View
Urease_alpha (PF00449) 4507 (2.1%) View
UxaC (PF02614) 2794 (1.3%) View
PTE (PF02126) 2308 (1.1%) View
CpsB_CapC (PF19567) 2209 (1.0%) View
RNase_P_p30 (PF01876) 2034 (1.0%) View
PHP_C (PF13263) 1790 (0.8%) View
DUF3604 (PF12228) 757 (0.4%) View
DUF6282 (PF19799) 585 (0.3%) View
DHOase (PF12890) 140 (0.1%) View
Total: 17 Total: 212063 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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