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0  structures 4159  species 0  interactions 5326  sequences 8  architectures

Clan: AmpE_CobD-like (CL0685)


AmpE/CobD like Add an annotation

This clan contains the AmpE bacterial family of signalling proteins. These proteins help to regulate beta-lactamase. It also contains the CobD/Cbib family of proteins which are involved in cobalamin biosynthesis. According to TCDB, members have 5 or 6 putative transmembrane regions.

This clan contains 2 families and the total number of domains in the clan is 5326. The clan was built by J Mistry.

Literature references

  1. Brushaber KR, O'Toole GA, Escalante-Semerena JC; , J Biol Chem 1998;273:2684-2691.: CobD, a novel enzyme with L-threonine-O-3-phosphate decarboxylase activity, is responsible for the synthesis of (R)-1-amino-2-propanol O-2-phosphate, a proposed new intermediate in cobalamin biosynthesis in Salmonella typhimurium LT2. PUBMED:9446573 EPMC:9446573
  2. Lindquist S, Galleni M, Lindberg F, Normark S;, Mol Microbiol. 1989;3:1091-1102.: Signalling proteins in enterobacterial AmpC beta-lactamase regulation. PUBMED:2691840 EPMC:2691840


This clan contains the following 2 member families:

AmpE CobD_Cbib

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CobD_Cbib (PF03186) 4898 (92.0%) View
AmpE (PF17113) 428 (8.0%) View
Total: 2 Total: 5326 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...