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237  structures 7093  species 0  interactions 33525  sequences 284  architectures

Clan: Aquaporin-like (CL0716)


Aquaporin-like superfamily Add an annotation

This clan groups families with an aquaporin-like structure comprising the canonical right-handed bundle of 6 transmembrane (TM) alpha-helices from aquaporins [1,2,3].

This clan contains 3 families and the total number of domains in the clan is 33525. The clan was built by S Chuguransky.

Literature references

  1. de Mare SW, Venskutonyte R, Eltschkner S, de Groot BL, Lindkvist-Petersson K;, Structure. 2020;28:215-222.: Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7. PUBMED:31831212 EPMC:31831212
  2. Gotfryd K, Mosca AF, Missel JW, Truelsen SF, Wang K, Spulber M, Krabbe S, Helix-Nielsen C, Laforenza U, Soveral G, Pedersen PA, Gourdon P;, Nat Commun. 2018;9:4749.: Human adipose glycerol flux is regulated by a pH gate in AQP10. PUBMED:30420639 EPMC:30420639
  3. Czyzewski BK, Wang DN;, Nature. 2012;483:494-497.: Identification and characterization of a bacterial hydrosulphide ion channel. PUBMED:22407320 EPMC:22407320


This clan contains the following 3 member families:

Form_Nir_trans MIP SpecificRecomb

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
MIP (PF00230) 27928 (83.3%) View
Form_Nir_trans (PF01226) 5017 (15.0%) View
SpecificRecomb (PF10136) 580 (1.7%) View
Total: 3 Total: 33525 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...