Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
18  structures 3025  species 0  interactions 7300  sequences 227  architectures

Clan: ArdcN (CL0700)


ArdcN superfamily Add an annotation

This superfamily is related to the ArdC N_terminal domain.

This clan contains 4 families and the total number of domains in the clan is 7300. The clan was built by L Aravind.

Literature references

  1. Krishnan A, Burroughs AM, Iyer LM, Aravind L;, iScience. 2018;9:192-208.: Unexpected Evolution of Lesion-Recognition Modules in Eukaryotic NER and Kinetoplast DNA Dynamics Proteins from Bacterial Mobile Elements. PUBMED:30396152 EPMC:30396152
  2. Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L;, J Bacteriol. 2017; [Epub ahead of print]: Polyvalent Proteins, a Pervasive Theme in the Intergenomic Biological Conflicts of Bacteriophages and Conjugative Elements. PUBMED:28559295 EPMC:28559295


This clan contains the following 4 member families:

ArdcN BHD_1 BHD_2 Tc-38

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ArdcN (PF08401) 3021 (41.4%) View
BHD_1 (PF10403) 2221 (30.4%) View
BHD_2 (PF10404) 1879 (25.7%) View
Tc-38 (PF20054) 179 (2.5%) View
Total: 4 Total: 7300 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...