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104  structures 2463  species 0  interactions 30167  sequences 303  architectures

Clan: Arrestin_N-like (CL0135)


Arrestin_N-like Add an annotation

The families in this clan are involved in vacuolar protein trafficking, G protein signal termination and sporulation. The Arrestin N terminal domain has an Ig-like beta sandwich fold which binds to receptors and impairs their capacity to active G proteins [1]. Arrestins have also been implicated in the endocytosis of receptors and cross talk with other signalling pathways [2].

This clan contains 7 families and the total number of domains in the clan is 30167. The clan was built by J Mistry.

Literature references

  1. Granzin J, Wilden U, Choe HW, Labahn J, Krafft B, Buldt G; , Nature 1998;391:918-921.: X-ray crystal structure of arrestin from bovine rod outer segments. PUBMED:9495348 EPMC:9495348
  2. Claing A, Laporte SA, Caron MG, Lefkowitz RJ; , Prog Neurobiol 2002;66:61-79.: Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. PUBMED:11900882 EPMC:11900882
  3. Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI; , Mol Biol Cell 2000;11:4105-4116.: Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. PUBMED:11102511 EPMC:11102511
  4. Han WD, Kawamoto S, Hosoya Y, Fujita M, Sadaie Y, Suzuki K, Ohashi Y, Kawamura F, Ochi K; , Gene 1998;217:31-40.: A novel sporulation-control gene (spo0M) of Bacillus subtilis with a sigmaH-regulated promoter. PUBMED:9795118 EPMC:9795118


This clan contains the following 7 member families:

Arrestin_C Arrestin_N Bul1_N LDB19 Rgp1 Spo0M Vps26

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Arrestin_N (PF00339) 11253 (37.3%) View
Arrestin_C (PF02752) 10695 (35.5%) View
Vps26 (PF03643) 3599 (11.9%) View
Rgp1 (PF08737) 2108 (7.0%) View
Spo0M (PF07070) 1683 (5.6%) View
LDB19 (PF13002) 557 (1.8%) View
Bul1_N (PF04425) 272 (0.9%) View
Total: 7 Total: 30167 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...