Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 581  species 0  interactions 880  sequences 128  architectures

Clan: BECR (CL0688)


Barnase-EndoU-ColicinE5/D-RelE like nuclease Add an annotation

This clan includes RNase of the barnase/EndoU/colicin E5/D-RelE (BECR)-like fold. The BECR fold of metal-independent endoRNases are commonly observed and extensively diversified effectors across diverse prokaryotic conflict systems such as polymorphic toxin systems, plasmid-encoded bacteriocins, and TA systems. Although BECR fold proteins are often extensively elaborated with inserts or show structural modifications, they share a conserved core of an N-terminal helix followed by four or five strands. In addition to their presence in polyvalent proteins, solo versions of these BECR domains are also found in phages; we accordingly designate this clade the phage-BECR (PBECR) domains [1].

This clan contains 7 families and the total number of domains in the clan is 880. The clan was built by S El-Gebali.

Literature references

  1. Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L;, J Bacteriol. 2017; [Epub ahead of print]: Polyvalent Proteins, a Pervasive Theme in the Intergenomic Biological Conflicts of Bacteriophages and Conjugative Elements. PUBMED:28559295 EPMC:28559295


This clan contains the following 7 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PBECR3 (PF18812) 207 (23.5%) View
PBECR2 (PF18810) 202 (23.0%) View
PBECR4 (PF18813) 186 (21.1%) View
MuF_C (PF18819) 154 (17.5%) View
PBECR1 (PF18809) 103 (11.7%) View
PBECR5 (PF18814) 14 (1.6%) View
DUF3519 (PF12033) 14 (1.6%) View
Total: 7 Total: 880 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...