Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
741  structures 2586  species 0  interactions 233393  sequences 3965  architectures

Clan: C2 (CL0154)


C2 superfamily Add an annotation

This superfamily includes C2 domains and C2-like domains.

This clan contains 18 families and the total number of domains in the clan is 233393. The clan was built by A Bateman.

Literature references

  1. Ponting CP, Parker PJ; , Protein Sci 1996;5:162-166.: Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin. PUBMED:8771209 EPMC:8771209
  2. Zhang D, Aravind L;, Gene. 2010;469:18-30.: Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes. PUBMED:20713135 EPMC:20713135


This clan contains the following 18 member families:

Aida_C2 Anillin B9-C2 C2 C2-C2_1 CC2D2AN-C2 CEP76-C2 DOCK-C2 IcmF_C MNNL NT-C2 PI3K_C2 PTEN_C2 pYEATS RPGR1_C SPATA6 Spond_N YEATS

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
C2 (PF00168) 183893 (78.8%) View
DOCK-C2 (PF14429) 10538 (4.5%) View
PTEN_C2 (PF10409) 7331 (3.1%) View
NT-C2 (PF10358) 5986 (2.6%) View
PI3K_C2 (PF00792) 5739 (2.5%) View
YEATS (PF03366) 4285 (1.8%) View
MNNL (PF07657) 2906 (1.2%) View
Anillin (PF08174) 2549 (1.1%) View
Spond_N (PF06468) 2152 (0.9%) View
B9-C2 (PF07162) 2113 (0.9%) View
IcmF_C (PF06744) 1279 (0.5%) View
SPATA6 (PF14909) 945 (0.4%) View
C2-C2_1 (PF11618) 893 (0.4%) View
CC2D2AN-C2 (PF15625) 821 (0.4%) View
RPGR1_C (PF18111) 814 (0.3%) View
Aida_C2 (PF14186) 576 (0.2%) View
CEP76-C2 (PF15627) 499 (0.2%) View
pYEATS (PF20305) 74 (0.0%) View
Total: 18 Total: 233393 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...