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220  structures 1579  species 0  interactions 93243  sequences 2011  architectures

Clan: CH (CL0188)


Calponin homology domain Add an annotation

The calponin homology (CH) domain is found in a variety of contexts, ranging from proteins involved in signalling pathways to cytoskeletal proteins. They seem to have diverse cellular functions, which are thought to include actin binding, involvement in the MAP kinase signalling pathway, and regulation of GEF activity in Rho family GTPase pathways. Structurally, they are organised into three layers, with two parallel alpha helices in the core being sandwiched between another two helices, one on each side [1].

This clan contains 9 families and the total number of domains in the clan is 93243. The clan was built by M Fenech.

Literature references

  1. Gimona M, Djinovic-Carugo K, Kranewitter WJ, Winder SJ; , FEBS Lett 2002;513:98-106.: Functional plasticity of CH domains. PUBMED:11911887 EPMC:11911887


This clan contains the following 9 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CH (PF00307) 81050 (86.9%) View
CAMSAP_CH (PF11971) 4062 (4.4%) View
CH_2 (PF06294) 1790 (1.9%) View
Ndc80_HEC (PF03801) 1688 (1.8%) View
Nuf2 (PF03800) 1669 (1.8%) View
MIP-T3 (PF10243) 961 (1.0%) View
CDC24 (PF06395) 809 (0.9%) View
IFT81_CH (PF18383) 753 (0.8%) View
DUF5745 (PF19016) 461 (0.5%) View
Total: 9 Total: 93243 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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