Summary
Leucine Rich Repeat
Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. This Pfam entry contains Leucine Rich Repeats not recognised by the Pfam:PF00560 model.
This clan contains 18 families and the total number of domains in the clan is 687014. The clan was built by DJ Studholme.
Literature references
- Kobe B, Deisenhofer J; , Trends Biochem Sci 1994;19:415-421.: The leucine-rich repeat: a versatile binding motif. PUBMED:7817399 EPMC:7817399
- Kobe B, Deisenhofer J; , Nature 1993;366:751-756.: Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. PUBMED:8264799 EPMC:8264799
Members
This clan contains the following 18 member families:
DUF285 FBXL18_LRR FNIP LRR_1 LRR_10 LRR_11 LRR_12 LRR_2 LRR_3 LRR_4 LRR_5 LRR_6 LRR_8 LRR_9 LRR_RI_capping Recep_L_domain Transp_inhibit TTSSLRRExternal database links
CATH: | 3.80.10.10 |
SCOP: | 50246 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
LRR_8 (PF13855) | 426470 (62.1%) | View |
LRR_6 (PF13516) | 143769 (20.9%) | View |
LRR_5 (PF13306) | 27077 (3.9%) | View |
LRR_1 (PF00560) | 26691 (3.9%) | View |
LRR_4 (PF12799) | 14031 (2.0%) | View |
LRR_9 (PF14580) | 13497 (2.0%) | View |
Recep_L_domain (PF01030) | 11867 (1.7%) | View |
FNIP (PF05725) | 7842 (1.1%) | View |
DUF285 (PF03382) | 7392 (1.1%) | View |
LRR_2 (PF07723) | 3198 (0.5%) | View |
LRR_3 (PF07725) | 2555 (0.4%) | View |
Transp_inhibit (PF18791) | 1482 (0.2%) | View |
FBXL18_LRR (PF19729) | 458 (0.1%) | View |
LRR_12 (PF18837) | 287 (0.0%) | View |
LRR_RI_capping (PF18779) | 221 (0.0%) | View |
LRR_11 (PF18831) | 111 (0.0%) | View |
TTSSLRR (PF12468) | 43 (0.0%) | View |
LRR_10 (PF18805) | 23 (0.0%) | View |
Total: 18 | Total: 687014 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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