Summary
His Kinase A (phospho-acceptor) domain
This is the dimerisation and phospho-acceptor domain of a sub-family of histidine kinases. It shares sequence similarity with Pfam:PF00512 and Pfam:PF07536. It is usually found adjacent to a C-terminal ATPase domain (Pfam:PF02518). This domain is found in a wide range of Bacteria and also several Archaea. It comprises one of the fundamental units of the two-component signal transduction system [2-7].
This clan contains 11 families and the total number of domains in the clan is 607278. The clan was built by DJ Studholme.
Literature references
- Grebe TW, Stock JB; , Adv Microb Physiol 1999;41:139-227.: The histidine protein kinase superfamily. PUBMED:10500846 EPMC:10500846
- Hwang I, Chen HC, Sheen J; , Plant Physiol 2002;129:500-515.: Two-component signal transduction pathways in Arabidopsis. PUBMED:12068096 EPMC:12068096
- Lohrmann J, Harter K; , Plant Physiol 2002;128:363-369.: Plant two-component signaling systems and the role of response regulators. PUBMED:11842140 EPMC:11842140
- Santos JL, Shiozaki K; , Sci STKE 2001;2001:RE1.: Fungal histidine kinases. PUBMED:11752677 EPMC:11752677
- West AH, Stock AM; , Trends Biochem Sci 2001;26:369-376.: Histidine kinases and response regulator proteins in two-component signaling systems. PUBMED:11406410 EPMC:11406410
- Rodrigue A, Quentin Y, Lazdunski A, Mejean V, Foglino M; , Trends Microbiol 2000;8:498-504.: Two-component systems in Pseudomonas aeruginosa: why so many?. PUBMED:11121759 EPMC:11121759
- Stock AM, Robinson VL, Goudreau PN; , Annu Rev Biochem 2000;69:183-215.: Two-component signal transduction. PUBMED:10966457 EPMC:10966457
Members
This clan contains the following 11 member families:
H-kinase_dim HATPase_c HATPase_c_2 HATPase_c_3 HATPase_c_4 HATPase_c_5 HisKA HisKA_2 HisKA_3 HPTransfase HWE_HKExternal database links
CATH: | 1.10.287.240 |
SCOP: | 47384 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
HATPase_c (PF02518) | 300774 (49.5%) | View |
HisKA (PF00512) | 188697 (31.1%) | View |
HisKA_3 (PF07730) | 42435 (7.0%) | View |
HATPase_c_2 (PF13581) | 27413 (4.5%) | View |
HATPase_c_3 (PF13589) | 22546 (3.7%) | View |
HisKA_2 (PF07568) | 6292 (1.0%) | View |
H-kinase_dim (PF02895) | 5921 (1.0%) | View |
HWE_HK (PF07536) | 4330 (0.7%) | View |
HATPase_c_5 (PF14501) | 4178 (0.7%) | View |
HATPase_c_4 (PF13749) | 3579 (0.6%) | View |
HPTransfase (PF10090) | 1113 (0.2%) | View |
Total: 11 | Total: 607278 | Clan alignment |
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Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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