Summary
Common phosphate binding-site TIM barrel superfamily
This large superfamily of TIM barrel enzymes all contain a common phosphate binding site. The phosphate is found in a variety of cofactors and ligands such as FMN [1,2].
This clan contains 61 families and the total number of domains in the clan is 677371. The clan was built by A Bateman.
Literature references
- Copley RR, Bork P; , J Mol Biol 2000;303:627-641.: Homology among (betaalpha)(8) barrels: implications for the evolution of metabolic pathways. PUBMED:11054297 EPMC:11054297
- Bork P, Gellerich J, Groth H, Hooft R, Martin F; , Protein Sci 1995;4:268-274.: Divergent evolution of a beta/alpha-barrel subclass: detection of numerous phosphate-binding sites by motif search. PUBMED:7757015 EPMC:7757015
Members
This clan contains the following 61 member families:
4HFCP_synth Ala_racemase_N ALAD Aldolase AP_endonuc_2 BtpA CdhD ComA CutC DAHP_synth_1 DAHP_synth_2 DeoC DHDPS DHO_dh DHquinase_I DUF2090 DUF4862 DUF561 DUF692 DUF993 Dus F_bP_aldolase FMN_dh G3P_antiterm GatZ_KbaZ-like Glu_syn_central Glu_synthase His_biosynth HMGL-like IGPS IMPDH KDGP_aldolase Lys-AminoMut_A MtrH NanE NAPRTase NeuB NMO OAM_alpha OMPdecase Orn_Arg_deC_N Oxidored_FMN PcrB PdxJ PRAI PRMT5_TIM Pterin_bind QRPTase_C Radical_SAM Radical_SAM_2 RhaA Ribul_P_3_epim SOR_SNZ TAL_FSA ThiC_Rad_SAM ThiG TIM TMP-TENI Trp_syntA UvdE UxuAExternal database links
CATH: | 3.20.20.90 |
SCOP: | 51395 63892 51351 51391 51412 51419 51690 51366 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
DAHP_synth_2 (PF01474) | 5743 (0.8%) | View |
ThiC_Rad_SAM (PF01964) | 5545 (0.8%) | View |
ThiG (PF05690) | 5129 (0.8%) | View |
SOR_SNZ (PF01680) | 4493 (0.7%) | View |
DHquinase_I (PF01487) | 4257 (0.6%) | View |
PdxJ (PF03740) | 4181 (0.6%) | View |
NeuB (PF03102) | 4001 (0.6%) | View |
CutC (PF03932) | 3971 (0.6%) | View |
UxuA (PF03786) | 3251 (0.5%) | View |
DUF692 (PF05114) | 2720 (0.4%) | View |
PRMT5_TIM (PF17285) | 2010 (0.3%) | View |
UvdE (PF03851) | 1691 (0.2%) | View |
NanE (PF04131) | 1505 (0.2%) | View |
ComA (PF02679) | 1301 (0.2%) | View |
BtpA (PF03437) | 1293 (0.2%) | View |
PcrB (PF01884) | 1254 (0.2%) | View |
G3P_antiterm (PF04309) | 1204 (0.2%) | View |
DUF993 (PF06187) | 1072 (0.2%) | View |
Radical_SAM_2 (PF19238) | 918 (0.1%) | View |
RhaA (PF06134) | 776 (0.1%) | View |
DUF2090 (PF09863) | 739 (0.1%) | View |
CdhD (PF03599) | 694 (0.1%) | View |
GatZ_KbaZ-like (PF08013) | 652 (0.1%) | View |
Lys-AminoMut_A (PF09043) | 585 (0.1%) | View |
4HFCP_synth (PF04476) | 464 (0.1%) | View |
DUF561 (PF04481) | 383 (0.1%) | View |
KDGP_aldolase (PF07071) | 331 (0.0%) | View |
OAM_alpha (PF16552) | 145 (0.0%) | View |
MtrH (PF02007) | 142 (0.0%) | View |
DUF4862 (PF16154) | 140 (0.0%) | View |
Total: 61 | Total: 677371 |
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Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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