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2831  structures 9818  species 0  interactions 83030  sequences 1413  architectures

Clan: Lysozyme (CL0037)


Lysozyme-like superfamily Add an annotation

Barley chitinase, bacterial chitosanase, and lysozymes from phage and animals all hydrolyse related polysaccharides. The proteins little amino-acid similarity, but have a structurally invariant core consisting of two helices and a three-stranded beta-sheet which form the substrate-binding and catalytic cleft [1].

This clan contains 21 families and the total number of domains in the clan is 83030. The clan was built by A Bateman.

Literature references

  1. Monzingo AF, Marcotte EM, Hart PJ, Robertus JD; , Nat Struct Biol 1996;3:133-140.: Chitinases, chitosanases, and lysozymes can be divided into procaryotic and eucaryotic families sharing a conserved core. PUBMED:8564539 EPMC:8564539


This clan contains the following 21 member families:

Destabilase DUF3218 Glucosaminidase Glyco_hydro_108 Glyco_hydro_19 Glyco_hydro_46 Glyco_hydro_80 Lys Lysozyme_like Peptidase_U40 Pesticin Phage_lysozyme Phage_lysozyme2 SLT SLT_2 SLT_3 SLT_4 TraH_2 Transgly Transglycosylas Utp11

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SLT (PF01464) 25454 (30.7%) View
Transgly (PF00912) 23347 (28.1%) View
SLT_2 (PF13406) 6996 (8.4%) View
Glucosaminidase (PF01832) 5902 (7.1%) View
Glyco_hydro_19 (PF00182) 5306 (6.4%) View
Transglycosylas (PF06737) 3620 (4.4%) View
Phage_lysozyme (PF00959) 3159 (3.8%) View
Lys (PF00062) 2181 (2.6%) View
Utp11 (PF03998) 1788 (2.2%) View
Glyco_hydro_108 (PF05838) 1411 (1.7%) View
SLT_4 (PF19489) 1021 (1.2%) View
Pfam family Num. domains Alignment
Glyco_hydro_46 (PF01374) 701 (0.8%) View
Phage_lysozyme2 (PF18013) 662 (0.8%) View
Lysozyme_like (PF13702) 575 (0.7%) View
Destabilase (PF05497) 524 (0.6%) View
SLT_3 (PF18896) 183 (0.2%) View
Pesticin (PF16754) 123 (0.1%) View
TraH_2 (PF06871) 73 (0.1%) View
Peptidase_U40 (PF10464) 2 (0.0%) View
DUF3218 (PF11508) 1 (0.0%) View
Glyco_hydro_80 (PF13647) 1 (0.0%) View
Total: 21 Total: 83030 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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