Summary
Copper amine oxidase, domains 1 and 2
Copper amine oxidase (CuAO) are comprised of three of four domains. In the case of the four domain CuAO, the N-terminal domain (termed N1, and is not present in the three domain CuAO) and the C-terminal catalytic domain sandwich two repeated domains (termed N2 and N3). The function of these two homologous domains is uncertain. N2 and N3 both have a cystatin-like fold [1].
This clan contains 3 families and the total number of domains in the clan is 9371. The clan was built by RD Finn.
Literature references
- Wilmot CM, Hajdu J, McPherson MJ, Knowles PF, Phillips SE; , Science 1999;286:1724-1728.: Visualization of dioxygen bound to copper during enzyme catalysis. PUBMED:10576737 EPMC:10576737
Members
This clan contains the following 3 member families:
Cu_amine_oxidN2 Cu_amine_oxidN3 DUF1965External database links
CATH: | 2.20.25.60 |
SCOP: | 54416 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
Loading domain graphics...
Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
Cu_amine_oxidN2 (PF02727) | 4508 (48.1%) | View |
Cu_amine_oxidN3 (PF02728) | 4355 (46.5%) | View |
DUF1965 (PF09248) | 508 (5.4%) | View |
Total: 3 | Total: 9371 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
Loading...
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
Loading structure mapping...