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5353  structures 8944  species 0  interactions 355662  sequences 9161  architectures

Clan: Glyco_hydro_tim (CL0058)

Summary

Tim barrel glycosyl hydrolase superfamily Add an annotation

This large superfamily contains a range of glycosyl hydrolase enzymes that possess a TIM barrel fold. This CLAN merges clans GH-A, GH-D, GH-H and GH-K from CAZy.

This clan contains 59 families and the total number of domains in the clan is 355662. The clan was built by A Bateman.

Literature references

  1. Naumov DG, Karreras M;, Mol Biol (Mosk). 2009;43:709-721.: [New program PSI protein classifier automatizes the PSI-BLAST results analysis]. PUBMED:19807035 EPMC:19807035

Members

This clan contains the following 59 member families:

Alpha-amylase Alpha_L_fucos Cellulase Cellulase-like Dehydratase_LU DUF1906 DUF4015 DUF4038 DUF4434 DUF4838 DUF4849 DUF5010 DUF5696 DUF6259 GHL10 GHL13 GHL15 GHL5 GHL6 Glyco_hydr_30_2 Glyco_hydro_1 Glyco_hydro_10 Glyco_hydro_101 Glyco_hydro_114 Glyco_hydro_129 Glyco_hydro_14 Glyco_hydro_17 Glyco_hydro_18 Glyco_hydro_20 Glyco_hydro_25 Glyco_hydro_26 Glyco_hydro_2_C Glyco_hydro_3 Glyco_hydro_30 Glyco_hydro_31 Glyco_hydro_35 Glyco_hydro_39 Glyco_hydro_42 Glyco_hydro_44 Glyco_hydro_53 Glyco_hydro_56 Glyco_hydro_59 Glyco_hydro_66 Glyco_hydro_70 Glyco_hydro_71 Glyco_hydro_72 Glyco_hydro_77 Glyco_hydro_79n Glyco_hydro_85 Glyco_hydro_97 Glyco_hydro_99 Glyco_hydro_cc Glyco_tran_WbsX hDGE_amylase Melibiase Melibiase_2 NAGidase NAGLU Raffinose_syn

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Alpha-amylase (PF00128) 60774 (17.1%) View
Glyco_hydro_3 (PF00933) 34208 (9.6%) View
Glyco_hydro_1 (PF00232) 29855 (8.4%) View
Glyco_hydro_18 (PF00704) 29293 (8.2%) View
Cellulase (PF00150) 21141 (5.9%) View
Glyco_hydro_31 (PF01055) 19731 (5.5%) View
Glyco_hydro_2_C (PF02836) 16222 (4.6%) View
Glyco_hydro_17 (PF00332) 13301 (3.7%) View
Glyco_hydro_20 (PF00728) 12671 (3.6%) View
Glyco_hydro_35 (PF01301) 11549 (3.2%) View
Melibiase_2 (PF16499) 8726 (2.5%) View
Alpha_L_fucos (PF01120) 8266 (2.3%) View
Glyco_hydro_10 (PF00331) 8106 (2.3%) View
Glyco_hydro_25 (PF01183) 6231 (1.8%) View
Glyco_hydro_77 (PF02446) 5507 (1.5%) View
Glyco_hydro_42 (PF02449) 5028 (1.4%) View
Melibiase (PF02065) 4782 (1.3%) View
Glyco_hydro_30 (PF02055) 4261 (1.2%) View
GHL10 (PF02638) 3472 (1.0%) View
Glyco_hydro_72 (PF03198) 3453 (1.0%) View
Raffinose_syn (PF05691) 3328 (0.9%) View
Glyco_hydro_26 (PF02156) 2957 (0.8%) View
Glyco_hydro_cc (PF11790) 2885 (0.8%) View
Glyco_hydro_56 (PF01630) 2746 (0.8%) View
Glyco_hydro_14 (PF01373) 2699 (0.8%) View
Glyco_hydro_97 (PF10566) 2527 (0.7%) View
Glyco_hydro_114 (PF03537) 2514 (0.7%) View
Glyco_hydro_39 (PF01229) 2343 (0.7%) View
Glyco_hydro_79n (PF03662) 2294 (0.6%) View
Glyco_hydro_71 (PF03659) 2204 (0.6%) View
continued
Pfam family Num. domains Alignment
NAGLU (PF05089) 2164 (0.6%) View
NAGidase (PF07555) 2091 (0.6%) View
Glyco_hydro_53 (PF07745) 1935 (0.5%) View
hDGE_amylase (PF14701) 1849 (0.5%) View
Glyco_hydro_85 (PF03644) 1691 (0.5%) View
DUF1906 (PF08924) 1446 (0.4%) View
DUF4038 (PF13204) 1288 (0.4%) View
Glyco_hydr_30_2 (PF14587) 1253 (0.4%) View
Glyco_hydro_59 (PF02057) 1222 (0.3%) View
Glyco_hydro_99 (PF16317) 1046 (0.3%) View
DUF4015 (PF13200) 957 (0.3%) View
Glyco_tran_WbsX (PF14307) 918 (0.3%) View
GHL6 (PF14871) 649 (0.2%) View
DUF4838 (PF16126) 532 (0.1%) View
DUF5696 (PF18952) 459 (0.1%) View
Glyco_hydro_101 (PF12905) 366 (0.1%) View
DUF4434 (PF14488) 336 (0.1%) View
Dehydratase_LU (PF02286) 300 (0.1%) View
Glyco_hydro_44 (PF12891) 300 (0.1%) View
GHL13 (PF14883) 294 (0.1%) View
GHL15 (PF14885) 267 (0.1%) View
Glyco_hydro_66 (PF13199) 259 (0.1%) View
DUF4849 (PF16141) 220 (0.1%) View
Glyco_hydro_129 (PF11308) 199 (0.1%) View
Cellulase-like (PF12876) 152 (0.0%) View
DUF6259 (PF19773) 151 (0.0%) View
GHL5 (PF14872) 147 (0.0%) View
Glyco_hydro_70 (PF02324) 62 (0.0%) View
DUF5010 (PF16402) 35 (0.0%) View
Total: 59 Total: 355662
No alignment ℹ
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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