Powering down the Pfam website
On October 5th, we began redirecting traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will remain available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
5353  structures 8944  species 0  interactions 355662  sequences 9161  architectures

Clan: Glyco_hydro_tim (CL0058)


Tim barrel glycosyl hydrolase superfamily Add an annotation

This large superfamily contains a range of glycosyl hydrolase enzymes that possess a TIM barrel fold. This CLAN merges clans GH-A, GH-D, GH-H and GH-K from CAZy.

This clan contains 59 families and the total number of domains in the clan is 355662. The clan was built by A Bateman.

Literature references

  1. Naumov DG, Karreras M;, Mol Biol (Mosk). 2009;43:709-721.: [New program PSI protein classifier automatizes the PSI-BLAST results analysis]. PUBMED:19807035 EPMC:19807035


This clan contains the following 59 member families:

Alpha-amylase Alpha_L_fucos Cellulase Cellulase-like Dehydratase_LU DUF1906 DUF4015 DUF4038 DUF4434 DUF4838 DUF4849 DUF5010 DUF5696 DUF6259 GHL10 GHL13 GHL15 GHL5 GHL6 Glyco_hydr_30_2 Glyco_hydro_1 Glyco_hydro_10 Glyco_hydro_101 Glyco_hydro_114 Glyco_hydro_129 Glyco_hydro_14 Glyco_hydro_17 Glyco_hydro_18 Glyco_hydro_20 Glyco_hydro_25 Glyco_hydro_26 Glyco_hydro_2_C Glyco_hydro_3 Glyco_hydro_30 Glyco_hydro_31 Glyco_hydro_35 Glyco_hydro_39 Glyco_hydro_42 Glyco_hydro_44 Glyco_hydro_53 Glyco_hydro_56 Glyco_hydro_59 Glyco_hydro_66 Glyco_hydro_70 Glyco_hydro_71 Glyco_hydro_72 Glyco_hydro_77 Glyco_hydro_79n Glyco_hydro_85 Glyco_hydro_97 Glyco_hydro_99 Glyco_hydro_cc Glyco_tran_WbsX hDGE_amylase Melibiase Melibiase_2 NAGidase NAGLU Raffinose_syn

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Alpha-amylase (PF00128) 60774 (17.1%) View
Glyco_hydro_3 (PF00933) 34208 (9.6%) View
Glyco_hydro_1 (PF00232) 29855 (8.4%) View
Glyco_hydro_18 (PF00704) 29293 (8.2%) View
Cellulase (PF00150) 21141 (5.9%) View
Glyco_hydro_31 (PF01055) 19731 (5.5%) View
Glyco_hydro_2_C (PF02836) 16222 (4.6%) View
Glyco_hydro_17 (PF00332) 13301 (3.7%) View
Glyco_hydro_20 (PF00728) 12671 (3.6%) View
Glyco_hydro_35 (PF01301) 11549 (3.2%) View
Melibiase_2 (PF16499) 8726 (2.5%) View
Alpha_L_fucos (PF01120) 8266 (2.3%) View
Glyco_hydro_10 (PF00331) 8106 (2.3%) View
Glyco_hydro_25 (PF01183) 6231 (1.8%) View
Glyco_hydro_77 (PF02446) 5507 (1.5%) View
Glyco_hydro_42 (PF02449) 5028 (1.4%) View
Melibiase (PF02065) 4782 (1.3%) View
Glyco_hydro_30 (PF02055) 4261 (1.2%) View
GHL10 (PF02638) 3472 (1.0%) View
Glyco_hydro_72 (PF03198) 3453 (1.0%) View
Raffinose_syn (PF05691) 3328 (0.9%) View
Glyco_hydro_26 (PF02156) 2957 (0.8%) View
Glyco_hydro_cc (PF11790) 2885 (0.8%) View
Glyco_hydro_56 (PF01630) 2746 (0.8%) View
Glyco_hydro_14 (PF01373) 2699 (0.8%) View
Glyco_hydro_97 (PF10566) 2527 (0.7%) View
Glyco_hydro_114 (PF03537) 2514 (0.7%) View
Glyco_hydro_39 (PF01229) 2343 (0.7%) View
Glyco_hydro_79n (PF03662) 2294 (0.6%) View
Glyco_hydro_71 (PF03659) 2204 (0.6%) View
Pfam family Num. domains Alignment
NAGLU (PF05089) 2164 (0.6%) View
NAGidase (PF07555) 2091 (0.6%) View
Glyco_hydro_53 (PF07745) 1935 (0.5%) View
hDGE_amylase (PF14701) 1849 (0.5%) View
Glyco_hydro_85 (PF03644) 1691 (0.5%) View
DUF1906 (PF08924) 1446 (0.4%) View
DUF4038 (PF13204) 1288 (0.4%) View
Glyco_hydr_30_2 (PF14587) 1253 (0.4%) View
Glyco_hydro_59 (PF02057) 1222 (0.3%) View
Glyco_hydro_99 (PF16317) 1046 (0.3%) View
DUF4015 (PF13200) 957 (0.3%) View
Glyco_tran_WbsX (PF14307) 918 (0.3%) View
GHL6 (PF14871) 649 (0.2%) View
DUF4838 (PF16126) 532 (0.1%) View
DUF5696 (PF18952) 459 (0.1%) View
Glyco_hydro_101 (PF12905) 366 (0.1%) View
DUF4434 (PF14488) 336 (0.1%) View
Dehydratase_LU (PF02286) 300 (0.1%) View
Glyco_hydro_44 (PF12891) 300 (0.1%) View
GHL13 (PF14883) 294 (0.1%) View
GHL15 (PF14885) 267 (0.1%) View
Glyco_hydro_66 (PF13199) 259 (0.1%) View
DUF4849 (PF16141) 220 (0.1%) View
Glyco_hydro_129 (PF11308) 199 (0.1%) View
Cellulase-like (PF12876) 152 (0.0%) View
DUF6259 (PF19773) 151 (0.0%) View
GHL5 (PF14872) 147 (0.0%) View
Glyco_hydro_70 (PF02324) 62 (0.0%) View
DUF5010 (PF16402) 35 (0.0%) View
Total: 59 Total: 355662
No alignment ℹ

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...