Summary
Beta-trefoil superfamily
This family corresponds to a large set of related beta-trefoil proteins [1]. The beta-trefoil is formed by six two-stranded hairpins [2]. Three of these form a barrel structure and the other three are in a triangular array that caps the barrel. The arrangement of the secondary structures gives the molecules a pseudo 3-fold axis.
This clan contains 23 families and the total number of domains in the clan is 71888. The clan was built by A Bateman.
Literature references
- Ponting CP, Russell RB; , J Mol Biol 2000;302:1041-1047.: Identification of distant homologues of fibroblast growth factors suggests a common ancestor for all beta-trefoil proteins. PUBMED:11183773 EPMC:11183773
- Murzin AG, Lesk AM, Chothia C; , J Mol Biol 1992;223:531-543.: beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors. PUBMED:1738162 EPMC:1738162
Members
This clan contains the following 23 member families:
AbfB Agglutinin Agglutinin_C Botulinum_HA-17 BTD CDtoxinA DUF569 Fascin FGF FRG1 IL1 IL33 Inhibitor_I48 Inhibitor_I66 Ins145_P3_rec Kunitz_legume Lectin_C_term Lipoprotein_11 MIR NTNH_C Ricin_B_lectin RicinB_lectin_2 Toxin_R_bind_CExternal database links
SCOP: | 50352 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
Ricin_B_lectin (PF00652) | 19009 (26.4%) | View |
RicinB_lectin_2 (PF14200) | 12801 (17.8%) | View |
MIR (PF02815) | 9884 (13.7%) | View |
FGF (PF00167) | 8734 (12.1%) | View |
Ins145_P3_rec (PF08709) | 5170 (7.2%) | View |
Fascin (PF06268) | 3763 (5.2%) | View |
AbfB (PF05270) | 2183 (3.0%) | View |
BTD (PF09270) | 1923 (2.7%) | View |
IL1 (PF00340) | 1857 (2.6%) | View |
Kunitz_legume (PF00197) | 1830 (2.5%) | View |
DUF569 (PF04601) | 1540 (2.1%) | View |
FRG1 (PF06229) | 1399 (1.9%) | View |
continued |
Pfam family | Num. domains | Alignment |
---|---|---|
Agglutinin (PF07468) | 790 (1.1%) | View |
Inhibitor_I66 (PF16850) | 358 (0.5%) | View |
IL33 (PF15095) | 220 (0.3%) | View |
Lipoprotein_11 (PF03260) | 143 (0.2%) | View |
CDtoxinA (PF03498) | 109 (0.2%) | View |
Inhibitor_I48 (PF10467) | 83 (0.1%) | View |
Agglutinin_C (PF18021) | 65 (0.1%) | View |
Botulinum_HA-17 (PF05588) | 9 (0.0%) | View |
Lectin_C_term (PF18022) | 6 (0.0%) | View |
NTNH_C (PF08470) | 6 (0.0%) | View |
Toxin_R_bind_C (PF07951) | 6 (0.0%) | View |
Total: 23 | Total: 71888 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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