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1593  structures 3316  species 0  interactions 71888  sequences 2468  architectures

Clan: Trefoil (CL0066)

Summary

Beta-trefoil superfamily Add an annotation

This family corresponds to a large set of related beta-trefoil proteins [1]. The beta-trefoil is formed by six two-stranded hairpins [2]. Three of these form a barrel structure and the other three are in a triangular array that caps the barrel. The arrangement of the secondary structures gives the molecules a pseudo 3-fold axis.

This clan contains 23 families and the total number of domains in the clan is 71888. The clan was built by A Bateman.

Literature references

  1. Ponting CP, Russell RB; , J Mol Biol 2000;302:1041-1047.: Identification of distant homologues of fibroblast growth factors suggests a common ancestor for all beta-trefoil proteins. PUBMED:11183773 EPMC:11183773
  2. Murzin AG, Lesk AM, Chothia C; , J Mol Biol 1992;223:531-543.: beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors. PUBMED:1738162 EPMC:1738162

Members

This clan contains the following 23 member families:

AbfB Agglutinin Agglutinin_C Botulinum_HA-17 BTD CDtoxinA DUF569 Fascin FGF FRG1 IL1 IL33 Inhibitor_I48 Inhibitor_I66 Ins145_P3_rec Kunitz_legume Lectin_C_term Lipoprotein_11 MIR NTNH_C Ricin_B_lectin RicinB_lectin_2 Toxin_R_bind_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ricin_B_lectin (PF00652) 19009 (26.4%) View
RicinB_lectin_2 (PF14200) 12801 (17.8%) View
MIR (PF02815) 9884 (13.7%) View
FGF (PF00167) 8734 (12.1%) View
Ins145_P3_rec (PF08709) 5170 (7.2%) View
Fascin (PF06268) 3763 (5.2%) View
AbfB (PF05270) 2183 (3.0%) View
BTD (PF09270) 1923 (2.7%) View
IL1 (PF00340) 1857 (2.6%) View
Kunitz_legume (PF00197) 1830 (2.5%) View
DUF569 (PF04601) 1540 (2.1%) View
FRG1 (PF06229) 1399 (1.9%) View
continued
Pfam family Num. domains Alignment
Agglutinin (PF07468) 790 (1.1%) View
Inhibitor_I66 (PF16850) 358 (0.5%) View
IL33 (PF15095) 220 (0.3%) View
Lipoprotein_11 (PF03260) 143 (0.2%) View
CDtoxinA (PF03498) 109 (0.2%) View
Inhibitor_I48 (PF10467) 83 (0.1%) View
Agglutinin_C (PF18021) 65 (0.1%) View
Botulinum_HA-17 (PF05588) 9 (0.0%) View
Lectin_C_term (PF18022) 6 (0.0%) View
NTNH_C (PF08470) 6 (0.0%) View
Toxin_R_bind_C (PF07951) 6 (0.0%) View
Total: 23 Total: 71888 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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