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392  structures 8677  species 0  interactions 95224  sequences 502  architectures

Clan: ACT (CL0070)


ACT-like domain Add an annotation

These domains are involved in binding to amino-acids and causing allosteric regulation of linked enzyme domains [1]. The relationship between these two families was first noticed in [2].

This clan contains 12 families and the total number of domains in the clan is 95224. The clan was built by A Bateman.

Literature references

  1. Anantharaman V, Koonin EV, Aravind L; , J Mol Biol 2001;307:1271-1292.: Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. PUBMED:11292341 EPMC:11292341
  2. Murzin AG, Bateman A; , Proteins 1997;1:105-112.: Distant homology recognition using structural classification of proteins. PUBMED:9485501 EPMC:9485501


This clan contains the following 12 member families:

ACT ACT_3 ACT_4 ACT_5 ACT_6 ACT_7 ACT_8 ALS_ss_C DUF493 NikR_C NIL Thr_dehydrat_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ACT (PF01842) 34234 (36.0%) View
ACT_7 (PF13840) 12908 (13.6%) View
ACT_4 (PF13291) 10187 (10.7%) View
ALS_ss_C (PF10369) 8911 (9.4%) View
Thr_dehydrat_C (PF00585) 7645 (8.0%) View
ACT_6 (PF13740) 5468 (5.7%) View
ACT_5 (PF13710) 5039 (5.3%) View
NIL (PF09383) 5025 (5.3%) View
DUF493 (PF04359) 2424 (2.5%) View
NikR_C (PF08753) 1379 (1.4%) View
ACT_8 (PF19571) 1105 (1.2%) View
ACT_3 (PF10000) 899 (0.9%) View
Total: 12 Total: 95224 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...