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392  structures 8677  species 0  interactions 95224  sequences 502  architectures

Clan: ACT (CL0070)

Summary

ACT-like domain Add an annotation

These domains are involved in binding to amino-acids and causing allosteric regulation of linked enzyme domains [1]. The relationship between these two families was first noticed in [2].

This clan contains 12 families and the total number of domains in the clan is 95224. The clan was built by A Bateman.

Literature references

  1. Anantharaman V, Koonin EV, Aravind L; , J Mol Biol 2001;307:1271-1292.: Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains. PUBMED:11292341 EPMC:11292341
  2. Murzin AG, Bateman A; , Proteins 1997;1:105-112.: Distant homology recognition using structural classification of proteins. PUBMED:9485501 EPMC:9485501

Members

This clan contains the following 12 member families:

ACT ACT_3 ACT_4 ACT_5 ACT_6 ACT_7 ACT_8 ALS_ss_C DUF493 NikR_C NIL Thr_dehydrat_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ACT (PF01842) 34234 (36.0%) View
ACT_7 (PF13840) 12908 (13.6%) View
ACT_4 (PF13291) 10187 (10.7%) View
ALS_ss_C (PF10369) 8911 (9.4%) View
Thr_dehydrat_C (PF00585) 7645 (8.0%) View
ACT_6 (PF13740) 5468 (5.7%) View
ACT_5 (PF13710) 5039 (5.3%) View
NIL (PF09383) 5025 (5.3%) View
DUF493 (PF04359) 2424 (2.5%) View
NikR_C (PF08753) 1379 (1.4%) View
ACT_8 (PF19571) 1105 (1.2%) View
ACT_3 (PF10000) 899 (0.9%) View
Total: 12 Total: 95224 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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