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797  structures 1385  species 0  interactions 31336  sequences 477  architectures

Clan: P53-like (CL0073)


Beta-sandwich DNA-binding domain Add an annotation

This clan contains a variety of DNA-binding domains that contain an immunoglobulin-like fold. It includes the DNA-binding domains of NF-kappaB, NFAT, p53, STAT-1, the T-domain and the Runt domain [1].

This clan contains 10 families and the total number of domains in the clan is 31336. The clan was built by A Bateman.

Literature references

  1. Berardi MJ, Sun C, Zehr M, Abildgaard F, Peng J, Speck NA, Bushweller JH; , Structure Fold Des 1999;7:1247-1256.: The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains. PUBMED:10545320 EPMC:10545320


This clan contains the following 10 member families:

Calmodulin_bind CEP1-DNA_bind LAG1-DNAbind NDT80_PhoG P53 PAD_M RHD_DNA_bind Runt STAT_bind T-box

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
T-box (PF00907) 8510 (27.2%) View
RHD_DNA_bind (PF00554) 5665 (18.1%) View
STAT_bind (PF02864) 3937 (12.6%) View
Calmodulin_bind (PF07887) 2812 (9.0%) View
NDT80_PhoG (PF05224) 2545 (8.1%) View
Runt (PF00853) 2297 (7.3%) View
P53 (PF00870) 2294 (7.3%) View
LAG1-DNAbind (PF09271) 2189 (7.0%) View
PAD_M (PF08527) 1080 (3.4%) View
CEP1-DNA_bind (PF09287) 7 (0.0%) View
Total: 10 Total: 31336 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...