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577  structures 498  species 0  interactions 28387  sequences 264  architectures

Clan: Cystine-knot (CL0079)


Cystine-knot cytokine superfamily Add an annotation

The cytokine families in this clan have the cystine-knot fold. In this 6 cysteines form three disulphide bridges that are interlinked.

This clan contains 14 families and the total number of domains in the clan is 28387. The clan was built by A Bateman.

Literature references

  1. Sun PD, Davies DR; , Annu Rev Biophys Biomol Struct 1995;24:269-291.: The cystine-knot growth-factor superfamily. PUBMED:7663117 EPMC:7663117
  2. McDonald NQ, Hendrickson WA; , Cell 1993;73:421-424.: A structural superfamily of growth factors containing a cystine knot motif. PUBMED:8490958 EPMC:8490958


This clan contains the following 14 member families:

Coagulin Cys_knot Cys_Knot_tox D_CNTX DAN Hormone_6 IL17 m_DGTX_Dc1a_b_c NGF Noggin PDGF Sclerostin Spaetzle TGF_beta

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TGF_beta (PF00019) 12309 (43.4%) View
PDGF (PF00341) 4199 (14.8%) View
Cys_knot (PF00007) 4182 (14.7%) View
IL17 (PF06083) 1903 (6.7%) View
DAN (PF03045) 1741 (6.1%) View
NGF (PF00243) 1259 (4.4%) View
Spaetzle (PF16077) 1005 (3.5%) View
Noggin (PF05806) 744 (2.6%) View
Sclerostin (PF05463) 635 (2.2%) View
Hormone_6 (PF00236) 410 (1.4%) View
D_CNTX (PF17492) 0 (0.0%) View
m_DGTX_Dc1a_b_c (PF17491) 0 (0.0%) View
Cys_Knot_tox (PF17486) 0 (0.0%) View
Coagulin (PF02035) 0 (0.0%) View
Total: 14 Total: 28387 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...