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934  structures 5079  species 0  interactions 10965  sequences 95  architectures

Clan: MIF (CL0082)


Tautomerase/MIF superfamily Add an annotation

This clan groups 5-(carboxymethyl)-2-hydroxymuconate isomerase (CHMI) and 4-oxalocrotonate tautomerase (4-OT) with macrophage inhibitory factor (MIF). Interestingly they all share an amino-terminal proline. Members of this clan for homotrimers [1].

This clan contains 6 families and the total number of domains in the clan is 10965. The clan was built by A Bateman.

Literature references

  1. Sugimoto H, Taniguchi M, Nakagawa A, Tanaka I, Suzuki M, Nishihira J; , Biochemistry 1999;38:3268-3279.: Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution. PUBMED:10079069 EPMC:10079069


This clan contains the following 6 member families:

CHMI DUF1904 MIF Tautomerase Tautomerase_2 Tautomerase_3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Tautomerase (PF01361) 4310 (39.3%) View
MIF (PF01187) 2715 (24.8%) View
Tautomerase_2 (PF14552) 1550 (14.1%) View
CHMI (PF02962) 1194 (10.9%) View
Tautomerase_3 (PF14832) 892 (8.1%) View
DUF1904 (PF08921) 304 (2.8%) View
Total: 6 Total: 10965 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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