Summary
DHS-like NAD/FAD-binding domain
The members of this family adopt a Rossmann fold, similar to CLAN:CL0063. However, the members of this family are distinguished in that the FAD/NAD cofactor is bound in the opposite direction. In this arrangement, the adenosine moiety is found bound at the second half of the fold. In addition, the conserved GxGxxG motif found in classical NADP binding Rossmann folds is absent. Finally, another distinguishing characteristic is the formation of an internal hydrogen bond in the FAD molecule [1].
This clan contains 10 families and the total number of domains in the clan is 78056. The clan was built by RD Finn.
Literature references
- Dym O, Eisenberg D; , Protein Sci 2001;10:1712-1728.: Sequence-structure analysis of FAD-containing proteins. PUBMED:11514662 EPMC:11514662
Members
This clan contains the following 10 member families:
CO_dh DS DUF4917 ETF_alpha PNTB PPS_PS SIR2 SIR2_2 TPP_enzyme_M TPP_enzyme_M_2External database links
CATH: | 3.40.50.1220 |
SCOP: | 52467 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
TPP_enzyme_M (PF00205) | 32382 (41.5%) | View |
SIR2 (PF02146) | 19213 (24.6%) | View |
ETF_alpha (PF00766) | 10857 (13.9%) | View |
PNTB (PF02233) | 5960 (7.6%) | View |
DS (PF01916) | 3757 (4.8%) | View |
SIR2_2 (PF13289) | 3730 (4.8%) | View |
TPP_enzyme_M_2 (PF16582) | 1573 (2.0%) | View |
PPS_PS (PF02006) | 260 (0.3%) | View |
DUF4917 (PF16263) | 178 (0.2%) | View |
CO_dh (PF02552) | 146 (0.2%) | View |
Total: 10 | Total: 78056 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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