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360  structures 7991  species 0  interactions 66712  sequences 1002  architectures

Clan: NAD_Ferredoxin (CL0091)

Summary

Ferredoxin / Ferric reductase-like NAD binding Add an annotation

The Ferredoxin / Ferric reductase-like NAD binding domain is adopts a Rossmann like fold. However, these families have been excluded from the classical NAD(P) binding Rossmann clan (CLAN:CL0063), due to a divergence of the GxGxxG motif. In this clan, the motif phosphate binding motif is G-T/S-G-A/I-P. The changes in the motif are a reflection of the different way that the NAD(P)H is bound by this fold and the classical Rossmann fold [1,2].

This clan contains 4 families and the total number of domains in the clan is 66712. The clan was built by RD Finn.

Literature references

  1. Ingelman M, Bianchi V, Eklund H; , J Mol Biol 1997;268:147-157.: The three-dimensional structure of flavodoxin reductase from Escherichia coli at 1.7 A resolution. PUBMED:9149148 EPMC:9149148
  2. Dym O, Eisenberg D; , Protein Sci 2001;10:1712-1728.: Sequence-structure analysis of FAD-containing proteins. PUBMED:11514662 EPMC:11514662

Members

This clan contains the following 4 member families:

Colicin_M NAD_binding_1 NAD_binding_6 SIP

External database links

CATH: 3.40.50.80
SCOP: 52343

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
NAD_binding_1 (PF00175) 46932 (70.4%) View
NAD_binding_6 (PF08030) 14364 (21.5%) View
SIP (PF04954) 5401 (8.1%) View
Colicin_M (PF14859) 15 (0.0%) View
Total: 4 Total: 66712 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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