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360  structures 7991  species 0  interactions 66712  sequences 1002  architectures

Clan: NAD_Ferredoxin (CL0091)


Ferredoxin / Ferric reductase-like NAD binding Add an annotation

The Ferredoxin / Ferric reductase-like NAD binding domain is adopts a Rossmann like fold. However, these families have been excluded from the classical NAD(P) binding Rossmann clan (CLAN:CL0063), due to a divergence of the GxGxxG motif. In this clan, the motif phosphate binding motif is G-T/S-G-A/I-P. The changes in the motif are a reflection of the different way that the NAD(P)H is bound by this fold and the classical Rossmann fold [1,2].

This clan contains 4 families and the total number of domains in the clan is 66712. The clan was built by RD Finn.

Literature references

  1. Ingelman M, Bianchi V, Eklund H; , J Mol Biol 1997;268:147-157.: The three-dimensional structure of flavodoxin reductase from Escherichia coli at 1.7 A resolution. PUBMED:9149148 EPMC:9149148
  2. Dym O, Eisenberg D; , Protein Sci 2001;10:1712-1728.: Sequence-structure analysis of FAD-containing proteins. PUBMED:11514662 EPMC:11514662


This clan contains the following 4 member families:

Colicin_M NAD_binding_1 NAD_binding_6 SIP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
NAD_binding_1 (PF00175) 46932 (70.4%) View
NAD_binding_6 (PF08030) 14364 (21.5%) View
SIP (PF04954) 5401 (8.1%) View
Colicin_M (PF14859) 15 (0.0%) View
Total: 4 Total: 66712 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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