Summary
ALDH-like superfamily
The aldehyde dehydrogenases (ALDHs) are a superfamily of multimeric enzymes which catalyse the oxidation of a broad range of aldehydes into their corresponding carboxylic acids with the reduction of their cofactor, NAD(P) into NAD(P)H. The way that the NAD is bound is distinct from other NAD(P)-dependent oxidoreductases. The domain represented by this clan consists of two similar subdomains.
This clan contains 4 families and the total number of domains in the clan is 135677. The clan was built by RD Finn.
Members
This clan contains the following 4 member families:
Aldedh DUF1487 Histidinol_dh LuxCExternal database links
CATH: | 3.40.309.10 3.40.605.10 |
SCOP: | 53720 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
Aldedh (PF00171) | 124152 (91.5%) | View |
Histidinol_dh (PF00815) | 10125 (7.5%) | View |
LuxC (PF05893) | 1268 (0.9%) | View |
DUF1487 (PF07368) | 132 (0.1%) | View |
Total: 4 | Total: 135677 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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