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1151  structures 9293  species 0  interactions 372606  sequences 2108  architectures

Clan: Hybrid (CL0105)


Barrel sandwich hybrid superfamily Add an annotation

This superfamily contains proteins with a hybrid motif [1]. This motif is embedded in structurally diverse proteins.

This clan contains 26 families and the total number of domains in the clan is 372606. The clan was built by A Bateman.

Literature references

  1. Chothia C, Murzin AG; , Structure 1993;1:217-222.: New folds for all-beta proteins. PUBMED:8081735 EPMC:8081735


This clan contains the following 26 member families:

Apocytochr_F_C Biotin_carb_C Biotin_lipoyl Biotin_lipoyl_2 Complex1_51K CusB_dom_1 DUF2118 DUF2254 GARS_C GCV_H HlyD_2 HlyD_3 HlyD_D23 HlyD_D4 HMBD LAL_C2 NAPRTase_N NQRA OEP Peptidase_M23 PGM1_C PTS_EIIA_1 PurK_C PYNP_C QRPTase_N RnfC_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
OEP (PF02321) 70486 (18.9%) View
Biotin_lipoyl (PF00364) 66190 (17.8%) View
HlyD_D23 (PF16576) 44998 (12.1%) View
Peptidase_M23 (PF01551) 37395 (10.0%) View
Biotin_carb_C (PF02785) 28810 (7.7%) View
HlyD_3 (PF13437) 20676 (5.5%) View
Biotin_lipoyl_2 (PF13533) 16778 (4.5%) View
Complex1_51K (PF01512) 13374 (3.6%) View
GCV_H (PF01597) 10636 (2.9%) View
GARS_C (PF02843) 9625 (2.6%) View
QRPTase_N (PF02749) 8276 (2.2%) View
NAPRTase_N (PF17767) 7558 (2.0%) View
PurK_C (PF17769) 7254 (1.9%) View
PTS_EIIA_1 (PF00358) 6197 (1.7%) View
Pfam family Num. domains Alignment
PYNP_C (PF07831) 5056 (1.4%) View
HMBD (PF19335) 4943 (1.3%) View
CusB_dom_1 (PF00529) 4891 (1.3%) View
RnfC_N (PF13375) 2741 (0.7%) View
DUF2254 (PF10011) 2153 (0.6%) View
LAL_C2 (PF18603) 1490 (0.4%) View
NQRA (PF05896) 1459 (0.4%) View
HlyD_2 (PF12700) 852 (0.2%) View
Apocytochr_F_C (PF01333) 423 (0.1%) View
PGM1_C (PF18105) 316 (0.1%) View
DUF2118 (PF09891) 23 (0.0%) View
HlyD_D4 (PF16572) 6 (0.0%) View
Total: 26 Total: 372606 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...