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1801  structures 9362  species 0  interactions 394552  sequences 4772  architectures

Clan: GT-A (CL0110)


Glycosyl transferase clan GT-A Add an annotation

This is the GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold [1].

This clan contains 53 families and the total number of domains in the clan is 394552. The clan was built by A Bateman.

Literature references

  1. Liu J, Mushegian A; , Protein Sci 2003;12:1418-1431.: Three monophyletic superfamilies account for the majority of the known glycosyltransferases. PUBMED:12824488 EPMC:12824488


This clan contains the following 53 member families:

Anp1 Branch Caps_synth Cellulose_synt CgtA CHGN Chitin_synth_1 Chitin_synth_2 CofC CTP_transf_3 DUF2064 DUF273 DUF604 DUF6564 Fringe Galactosyl_T GlcNAc Gly_transf_sug Glyco_tranf_2_2 Glyco_tranf_2_3 Glyco_tranf_2_4 Glyco_tranf_2_5 Glyco_trans_2_3 Glyco_transf_15 Glyco_transf_21 Glyco_transf_24 Glyco_transf_25 Glyco_transf_34 Glyco_transf_43 Glyco_transf_49 Glyco_transf_6 Glyco_transf_64 Glyco_transf_7C Glyco_transf_7N Glyco_transf_8 Glyco_transf_88 Glyco_transf_92 Glycos_transf_2 GNT-I IspD Mannosyl_trans3 MGAT2 NTP_transf_3 NTP_transferase Nucleotid_trans Osmo_MPGsynth Pox_P35 RGP Rhamno_transf STELLO TcdA_TcdB UDP-g_GGTase UDPGP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Glycos_transf_2 (PF00535) 118497 (30.0%) View
NTP_transferase (PF00483) 48133 (12.2%) View
NTP_transf_3 (PF12804) 20541 (5.2%) View
Glyco_transf_8 (PF01501) 17083 (4.3%) View
Glyco_tranf_2_3 (PF13641) 15789 (4.0%) View
Galactosyl_T (PF01762) 13578 (3.4%) View
Branch (PF02485) 11747 (3.0%) View
Cellulose_synt (PF03552) 11666 (3.0%) View
CTP_transf_3 (PF02348) 8989 (2.3%) View
IspD (PF01128) 8794 (2.2%) View
Glyco_trans_2_3 (PF13632) 8185 (2.1%) View
UDPGP (PF01704) 7440 (1.9%) View
Gly_transf_sug (PF04488) 7426 (1.9%) View
Glyco_transf_7C (PF02709) 6670 (1.7%) View
Fringe (PF02434) 5870 (1.5%) View
Chitin_synth_2 (PF03142) 5504 (1.4%) View
Nucleotid_trans (PF03407) 4609 (1.2%) View
Glyco_transf_92 (PF01697) 4365 (1.1%) View
Glyco_tranf_2_4 (PF13704) 4347 (1.1%) View
Glyco_transf_7N (PF13733) 4221 (1.1%) View
Glyco_transf_49 (PF13896) 4203 (1.1%) View
Glyco_transf_64 (PF09258) 4106 (1.0%) View
Mannosyl_trans3 (PF11051) 4078 (1.0%) View
Glyco_transf_25 (PF01755) 3916 (1.0%) View
Glyco_transf_15 (PF01793) 3672 (0.9%) View
CHGN (PF05679) 3568 (0.9%) View
Glyco_transf_34 (PF05637) 3458 (0.9%) View
Pfam family Num. domains Alignment
Glyco_transf_43 (PF03360) 3356 (0.9%) View
Glyco_transf_21 (PF13506) 3083 (0.8%) View
Chitin_synth_1 (PF01644) 2957 (0.7%) View
DUF604 (PF04646) 2865 (0.7%) View
Glyco_transf_24 (PF18404) 2671 (0.7%) View
UDP-g_GGTase (PF06427) 2431 (0.6%) View
DUF2064 (PF09837) 2414 (0.6%) View
GNT-I (PF03071) 2084 (0.5%) View
Anp1 (PF03452) 2009 (0.5%) View
Glyco_transf_6 (PF03414) 1872 (0.5%) View
RGP (PF03214) 1320 (0.3%) View
CofC (PF01983) 1178 (0.3%) View
MGAT2 (PF05060) 1062 (0.3%) View
GlcNAc (PF11397) 985 (0.2%) View
Caps_synth (PF05704) 955 (0.2%) View
STELLO (PF03385) 689 (0.2%) View
DUF273 (PF03314) 603 (0.2%) View
Rhamno_transf (PF11316) 564 (0.1%) View
Glyco_tranf_2_5 (PF13712) 388 (0.1%) View
Glyco_tranf_2_2 (PF10111) 287 (0.1%) View
Osmo_MPGsynth (PF09488) 107 (0.0%) View
TcdA_TcdB (PF12919) 100 (0.0%) View
CgtA (PF06306) 39 (0.0%) View
Pox_P35 (PF03213) 38 (0.0%) View
Glyco_transf_88 (PF16849) 25 (0.0%) View
DUF6564 (PF20202) 15 (0.0%) View
Total: 53 Total: 394552
No alignment ℹ

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...