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4  structures 4853  species 0  interactions 14004  sequences 178  architectures

Clan: Yip1 (CL0112)


Yip1/YIF1-like Add an annotation

Yip1 and YIF1 are members of an integral membrane complex which bind to Ras-like GTPases and are required for membrane fusion of ER derived vesicles with the Golgi [1].

This clan contains 6 families and the total number of domains in the clan is 14004. The clan was built by RD Finn and J Mistry.

Literature references

  1. Barrowman J, Wang W, Zhang Y, Ferro-Novick S; , J Biol Chem. 2003;278:19878-19884.: The Yip1p.Yif1p complex is required for the fusion competence of endoplasmic reticulum-derived vesicles. PUBMED:12657649 EPMC:12657649


This clan contains the following 6 member families:

DUF1048 DUF1129 DUF1189 DUF1700 YIF1 Yip1

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Yip1 (PF04893) 8110 (57.9%) View
YIF1 (PF03878) 2536 (18.1%) View
DUF1700 (PF08006) 1403 (10.0%) View
DUF1048 (PF06304) 873 (6.2%) View
DUF1189 (PF06691) 644 (4.6%) View
DUF1129 (PF06570) 438 (3.1%) View
Total: 6 Total: 14004 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...