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2612  structures 9405  species 0  interactions 179389  sequences 1296  architectures

Clan: ClpP_crotonase (CL0127)


ClpP/Crotonase superfamily Add an annotation

This family includes several peptidases of peptidase clan SK as well as crotonase like proteins.

This clan contains 10 families and the total number of domains in the clan is 179389. The clan was built by A Bateman.

Literature references

  1. Kunin V, Chan B, Sitbon E, Lithwick G, Pietrokovski S; , J Mol Biol 2001;307:939-949.: Consistency analysis of similarity between multiple alignments: prediction of protein function and fold structure from analysis of local sequence motifs. PUBMED:11273712 EPMC:11273712
  2. Zhang H, Yang Z, Shen Y, Tong L; , Science 2003;299:2064-2067.: Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. PUBMED:12663926 EPMC:12663926


This clan contains the following 10 member families:

ACCA Carboxyl_trans CLP_protease ECH_1 ECH_2 MdcE Peptidase_S41 Peptidase_S49 Peptidase_S49_N SDH_sah

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ECH_1 (PF00378) 80773 (45.0%) View
Carboxyl_trans (PF01039) 29381 (16.4%) View
CLP_protease (PF00574) 21275 (11.9%) View
Peptidase_S41 (PF03572) 20699 (11.5%) View
Peptidase_S49 (PF01343) 11238 (6.3%) View
ECH_2 (PF16113) 7548 (4.2%) View
ACCA (PF03255) 5979 (3.3%) View
SDH_sah (PF01972) 1136 (0.6%) View
Peptidase_S49_N (PF08496) 858 (0.5%) View
MdcE (PF06833) 502 (0.3%) View
Total: 10 Total: 179389 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...