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824  structures 8511  species 0  interactions 150760  sequences 5036  architectures

Clan: vWA-like (CL0128)


von Willebrand factor type A Add an annotation

To add.

This clan contains 19 families and the total number of domains in the clan is 150760. The clan was built by RD Finn.

Literature references

  1. Whittaker CA, Hynes RO; , Mol Biol Cell 2002;13:3369-3387.: Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. PUBMED:12388743 EPMC:12388743


This clan contains the following 19 member families:

CobT_C Copine DUF1194 DUF2201 DUF444 DUF58 Integrin_beta ivWA Ku_N Med25_VWA Sec23_trunk Ssl1 Ste5_C Tfb4 VWA vWA-TerF-like VWA_2 VWA_3 VWA_CoxE

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
VWA (PF00092) 63476 (42.1%) View
VWA_2 (PF13519) 16523 (11.0%) View
DUF58 (PF01882) 14161 (9.4%) View
Sec23_trunk (PF04811) 10036 (6.7%) View
VWA_3 (PF13768) 9043 (6.0%) View
Copine (PF07002) 9031 (6.0%) View
VWA_CoxE (PF05762) 6056 (4.0%) View
Integrin_beta (PF00362) 5488 (3.6%) View
Ku_N (PF03731) 3475 (2.3%) View
DUF444 (PF04285) 2893 (1.9%) View
Tfb4 (PF03850) 1949 (1.3%) View
Ssl1 (PF04056) 1881 (1.2%) View
CobT_C (PF11775) 1584 (1.1%) View
DUF2201 (PF09967) 1360 (0.9%) View
DUF1194 (PF06707) 1346 (0.9%) View
Med25_VWA (PF11265) 1332 (0.9%) View
vWA-TerF-like (PF10138) 1081 (0.7%) View
Ste5_C (PF12194) 29 (0.0%) View
ivWA (PF19997) 16 (0.0%) View
Total: 19 Total: 150760 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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