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1811  structures 9100  species 0  interactions 138201  sequences 731  architectures

Clan: GADPH_aa-bio_dh (CL0139)


Amino acid biosynthesis and glycosomal dehydrogenase Add an annotation

This clan contains the C terminal domains of dehydrogenase enzymes involved in the biosynthesis of arginine, aspartate and aspartate derived amino acids. It also contains the C terminal domain of GAPDH, a dehydrogenase involved in glycolysis and gluconeogenesis.

This clan contains 18 families and the total number of domains in the clan is 138201. The clan was built by J Mistry.

Literature references

  1. Novotna J, Jandova A, Janouskova M, Laurova L, Skoda V; , Cesk Gynekol 1976;41:733-734.: [Levels of DNA and RNA in the carcinomatous tissue of the collum uteri before and after application of Cytembena (author's transl)]. PUBMED:1036977 EPMC:1036977
  2. Kim H, Feil IK, Verlinde CL, Petra PH, Hol WG; , Biochemistry 1995;34:14975-14986.: Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: implications for structure-based drug design and a new position for the inorganic phosphate binding site. PUBMED:7578111 EPMC:7578111


This clan contains the following 18 member families:

AcetDehyd-dimer Asp_DH_C Biliv-reduc_cat DapB_C DAPDH_C DXP_redisom_C G6PD_C GFO_IDH_MocA_C GFO_IDH_MocA_C2 Gp_dh_C Homoserine_dh Inos-1-P_synth OpcA_G6PD_C ox_reductase_C Oxidoreduct_C OxRdtase_C Sacchrp_dh_C Semialdhyde_dhC

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GFO_IDH_MocA_C (PF02894) 41850 (30.3%) View
Gp_dh_C (PF02800) 19754 (14.3%) View
Semialdhyde_dhC (PF02774) 16042 (11.6%) View
G6PD_C (PF02781) 11331 (8.2%) View
Homoserine_dh (PF00742) 10618 (7.7%) View
DapB_C (PF05173) 8669 (6.3%) View
DXP_redisom_C (PF08436) 7124 (5.2%) View
Sacchrp_dh_C (PF16653) 6979 (5.0%) View
Inos-1-P_synth (PF01658) 4478 (3.2%) View
GFO_IDH_MocA_C2 (PF19051) 4350 (3.1%) View
OpcA_G6PD_C (PF20171) 1808 (1.3%) View
AcetDehyd-dimer (PF09290) 1685 (1.2%) View
Asp_DH_C (PF01958) 1266 (0.9%) View
DAPDH_C (PF16654) 958 (0.7%) View
ox_reductase_C (PF08635) 384 (0.3%) View
OxRdtase_C (PF19858) 369 (0.3%) View
Biliv-reduc_cat (PF09166) 358 (0.3%) View
Oxidoreduct_C (PF16490) 178 (0.1%) View
Total: 18 Total: 138201 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...