Summary
C2 superfamily
This superfamily includes C2 domains and C2-like domains.
This clan contains 18 families and the total number of domains in the clan is 233393. The clan was built by A Bateman.
Literature references
- Ponting CP, Parker PJ; , Protein Sci 1996;5:162-166.: Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin. PUBMED:8771209 EPMC:8771209
- Zhang D, Aravind L;, Gene. 2010;469:18-30.: Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes. PUBMED:20713135 EPMC:20713135
Members
This clan contains the following 18 member families:
Aida_C2 Anillin B9-C2 C2 C2-C2_1 CC2D2AN-C2 CEP76-C2 DOCK-C2 IcmF_C MNNL NT-C2 PI3K_C2 PTEN_C2 pYEATS RPGR1_C SPATA6 Spond_N YEATSExternal database links
CATH: | 2.60.40.150 |
SCOP: | 49562 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
C2 (PF00168) | 183893 (78.8%) | View |
DOCK-C2 (PF14429) | 10538 (4.5%) | View |
PTEN_C2 (PF10409) | 7331 (3.1%) | View |
NT-C2 (PF10358) | 5986 (2.6%) | View |
PI3K_C2 (PF00792) | 5739 (2.5%) | View |
YEATS (PF03366) | 4285 (1.8%) | View |
MNNL (PF07657) | 2906 (1.2%) | View |
Anillin (PF08174) | 2549 (1.1%) | View |
Spond_N (PF06468) | 2152 (0.9%) | View |
B9-C2 (PF07162) | 2113 (0.9%) | View |
IcmF_C (PF06744) | 1279 (0.5%) | View |
SPATA6 (PF14909) | 945 (0.4%) | View |
C2-C2_1 (PF11618) | 893 (0.4%) | View |
CC2D2AN-C2 (PF15625) | 821 (0.4%) | View |
RPGR1_C (PF18111) | 814 (0.3%) | View |
Aida_C2 (PF14186) | 576 (0.2%) | View |
CEP76-C2 (PF15627) | 499 (0.2%) | View |
pYEATS (PF20305) | 74 (0.0%) | View |
Total: 18 | Total: 233393 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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