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700  structures 8654  species 0  interactions 148524  sequences 8975  architectures

Clan: GAF (CL0161)


GAF domain-like Add an annotation

A clan of related transcriptional regulator domains.

This clan contains 18 families and the total number of domains in the clan is 148524. The clan was built by RD Finn.


This clan contains the following 18 member families:

Autoind_bind bHLH-MYC_N CCB2_CCB4 CodY DraK_HK_N DUF3369 DUF484 DUF5628 GAF GAF_2 GAF_3 HbpS-like HNOBA HrcA IclR PdtaS_GAF PHY SpoVT_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GAF (PF01590) 40137 (27.0%) View
GAF_2 (PF13185) 38856 (26.2%) View
IclR (PF01614) 28445 (19.2%) View
HbpS-like (PF03928) 6955 (4.7%) View
HrcA (PF01628) 5779 (3.9%) View
bHLH-MYC_N (PF14215) 4768 (3.2%) View
HNOBA (PF07701) 4707 (3.2%) View
GAF_3 (PF13492) 3687 (2.5%) View
PHY (PF00360) 3463 (2.3%) View
Autoind_bind (PF03472) 3268 (2.2%) View
DUF484 (PF04340) 2096 (1.4%) View
PdtaS_GAF (PF12282) 1668 (1.1%) View
SpoVT_C (PF15714) 1236 (0.8%) View
CodY (PF06018) 1185 (0.8%) View
DUF3369 (PF11849) 920 (0.6%) View
CCB2_CCB4 (PF11152) 715 (0.5%) View
DraK_HK_N (PF18092) 575 (0.4%) View
DUF5628 (PF18621) 64 (0.0%) View
Total: 18 Total: 148524 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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