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183  structures 1518  species 0  interactions 32354  sequences 1648  architectures

Clan: PAN (CL0168)


PAN-like Add an annotation

PAN domains have significant functional versatility fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions [1]. These domains contain a hair-pin loop like structure, similar to knottins, but the pattern of disulphide bonds differs.

This clan contains 6 families and the total number of domains in the clan is 32354. The clan was built by RD Finn.

Literature references

  1. Tordai H, Banyai L, Patthy L; , FEBS Lett 1999;461:63-67.: The PAN module: the N-terminal domains of plasminogen and hepatocyte growth factor are homologous with the apple domains of the prekallikrein family and with a novel domain found in numerous nematode proteins. PUBMED:10561497 EPMC:10561497


This clan contains the following 6 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PAN_2 (PF08276) 12970 (40.1%) View
PAN_1 (PF00024) 11531 (35.6%) View
PAN_4 (PF14295) 5691 (17.6%) View
MANEC (PF07502) 1385 (4.3%) View
PAN_3 (PF08277) 667 (2.1%) View
AMA-1 (PF02430) 110 (0.3%) View
Total: 6 Total: 32354 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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