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630  structures 8055  species 0  interactions 38455  sequences 268  architectures

Clan: Phospoesterase (CL0171)


inositol polyphosphate 1 phosphatase like superfamily Add an annotation

Members of this clan show metal-dependent / lithium sensitive phosphomonoesterase activity. The clan includes inositol polyphosphate 1 phosphatase and fructose 1,6-bisphosphatase [1].

This clan contains 3 families and the total number of domains in the clan is 38455. The clan was built by A Bateman.

Literature references

  1. York JD, Ponder JW, Majerus PW; , Proc Natl Acad Sci U S A 1995;92:5149-5153.: Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. PUBMED:7761465 EPMC:7761465


This clan contains the following 3 member families:

FBPase FBPase_glpX Inositol_P

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Inositol_P (PF00459) 27556 (71.7%) View
FBPase (PF00316) 6892 (17.9%) View
FBPase_glpX (PF03320) 4007 (10.4%) View
Total: 3 Total: 38455 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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