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5402  structures 9792  species 0  interactions 441968  sequences 4637  architectures

Clan: Thioredoxin (CL0172)


Thioredoxin-like Add an annotation

This clan contains families related to the thioredoxin family. Thioredoxins are small enzymes that are involved in redox reactions via the reversible oxidation of an active centre disulfide bond. The thioredoxin fold consists of a 3 layer alpha/beta/alpha sandwich and a central beta sheet.

This clan contains 65 families and the total number of domains in the clan is 441968. The clan was built by J Mistry.

Literature references

  1. Qi Y, Grishin NV; , Proteins 2005;58:376-388.: Structural classification of thioredoxin-like fold proteins. PUBMED:15558583 EPMC:15558583


This clan contains the following 65 member families:

2Fe-2S_thioredx AhpC-TSA AhpC-TSA_2 ArsC ArsD Calsequestrin DIM1 DSBA DUF1223 DUF1462 DUF1525 DUF1687 DUF2703 DUF2847 DUF4174 DUF6436 DUF6568 DUF899 DUF929 DUF953 ERp29_N GILT Glrx-like Glutaredoxin GSHPx GST_N GST_N_2 GST_N_3 GST_N_4 GST_N_5 HyaE KaiB L51_S25_CI-B8 MRP-S23 MRP-S25 OST3_OST6 Phe_hydrox_dim Phosducin QSOX_Trx1 Rdx Redoxin SCO1-SenC SelP_N Sep15_SelM SH3BGR T4_deiodinase Thioredox_DsbH Thioredoxin Thioredoxin_11 Thioredoxin_12 Thioredoxin_13 Thioredoxin_14 Thioredoxin_15 Thioredoxin_16 Thioredoxin_2 Thioredoxin_3 Thioredoxin_4 Thioredoxin_5 Thioredoxin_6 Thioredoxin_7 Thioredoxin_8 Thioredoxin_9 Tom37 TraF YtfJ_HI0045

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Thioredoxin (PF00085) 80736 (18.3%) View
AhpC-TSA (PF00578) 48207 (10.9%) View
GST_N (PF02798) 34909 (7.9%) View
Glutaredoxin (PF00462) 31317 (7.1%) View
GST_N_3 (PF13417) 30619 (6.9%) View
Redoxin (PF08534) 20243 (4.6%) View
DSBA (PF01323) 15736 (3.6%) View
2Fe-2S_thioredx (PF01257) 12505 (2.8%) View
GSHPx (PF00255) 12301 (2.8%) View
GST_N_2 (PF13409) 11425 (2.6%) View
Thioredoxin_4 (PF13462) 10569 (2.4%) View
SCO1-SenC (PF02630) 10548 (2.4%) View
ArsC (PF03960) 10136 (2.3%) View
Thioredoxin_7 (PF13899) 8807 (2.0%) View
Thioredoxin_6 (PF13848) 8228 (1.9%) View
Thioredoxin_8 (PF13905) 8043 (1.8%) View
Thioredox_DsbH (PF03190) 5519 (1.2%) View
Thioredoxin_3 (PF13192) 4394 (1.0%) View
Thioredoxin_2 (PF13098) 4156 (0.9%) View
Glrx-like (PF05768) 4082 (0.9%) View
L51_S25_CI-B8 (PF05047) 4072 (0.9%) View
Rdx (PF10262) 3761 (0.9%) View
Phosducin (PF02114) 3568 (0.8%) View
AhpC-TSA_2 (PF13911) 3238 (0.7%) View
OST3_OST6 (PF04756) 3177 (0.7%) View
Phe_hydrox_dim (PF07976) 3114 (0.7%) View
GILT (PF03227) 2899 (0.7%) View
DUF4174 (PF13778) 2804 (0.6%) View
DIM1 (PF02966) 2592 (0.6%) View
Thioredoxin_14 (PF18402) 2523 (0.6%) View
Thioredoxin_12 (PF18400) 2494 (0.6%) View
GST_N_4 (PF17172) 2487 (0.6%) View
Tom37 (PF10568) 2460 (0.6%) View
Pfam family Num. domains Alignment
Thioredoxin_13 (PF18401) 2453 (0.6%) View
SH3BGR (PF04908) 2411 (0.5%) View
DUF899 (PF05988) 2287 (0.5%) View
Thioredoxin_15 (PF18403) 2280 (0.5%) View
DUF1223 (PF06764) 1653 (0.4%) View
DUF953 (PF06110) 1555 (0.4%) View
T4_deiodinase (PF00837) 1503 (0.3%) View
Calsequestrin (PF01216) 1392 (0.3%) View
Thioredoxin_11 (PF18078) 1373 (0.3%) View
Thioredoxin_9 (PF14595) 1343 (0.3%) View
DUF2847 (PF11009) 1146 (0.3%) View
Thioredoxin_5 (PF13743) 1080 (0.2%) View
KaiB (PF07689) 1007 (0.2%) View
Sep15_SelM (PF08806) 978 (0.2%) View
MRP-S25 (PF13741) 870 (0.2%) View
QSOX_Trx1 (PF18108) 764 (0.2%) View
ArsD (PF06953) 727 (0.2%) View
DUF1687 (PF07955) 678 (0.2%) View
TraF (PF13728) 620 (0.1%) View
Thioredoxin_16 (PF18569) 588 (0.1%) View
GST_N_5 (PF18485) 547 (0.1%) View
SelP_N (PF04592) 544 (0.1%) View
MRP-S23 (PF10484) 525 (0.1%) View
ERp29_N (PF07912) 347 (0.1%) View
DUF1462 (PF07315) 342 (0.1%) View
YtfJ_HI0045 (PF09695) 276 (0.1%) View
HyaE (PF07449) 259 (0.1%) View
DUF1525 (PF07511) 222 (0.1%) View
DUF6436 (PF20029) 176 (0.0%) View
DUF2703 (PF10865) 166 (0.0%) View
DUF929 (PF06053) 133 (0.0%) View
DUF6568 (PF20207) 54 (0.0%) View
Total: 65 Total: 441968
No alignment ℹ

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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