Summary
STIR superfamily
Both members of this clan are thought to be involved in TOLL/IL1R-like pathways, by mediating protein-protein interactions between pathway components. The N-termini of SEFIR and TIR domains are similar, but the domains are more divergent towards the C-terminus [1].
This clan contains 6 families and the total number of domains in the clan is 34844. The clan was built by M Fenech.
Literature references
- Novatchkova M, Leibbrandt A, Werzowa J, Neubuser A, Eisenhaber F; , Trends Biochem Sci 2003;28:226-229.: The STIR-domain superfamily in signal transduction, development and immunity. PUBMED:12765832 EPMC:12765832
Members
This clan contains the following 6 member families:
DUF1863 SEFIR TIR TIR-like TIR_2 TIR_3External database links
SCOP: | 52200 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
TIR (PF01582) | 19886 (57.1%) | View |
TIR_2 (PF13676) | 9678 (27.8%) | View |
SEFIR (PF08357) | 2883 (8.3%) | View |
DUF1863 (PF08937) | 1078 (3.1%) | View |
TIR_3 (PF18567) | 666 (1.9%) | View |
TIR-like (PF10137) | 653 (1.9%) | View |
Total: 6 | Total: 34844 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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