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652  structures 9044  species 0  interactions 75226  sequences 853  architectures

Clan: PUA (CL0178)


PUA/ASCH superfamily Add an annotation

This clan consists of the RNA binding PUA domain and ASCH domain. It also contains uncharacterised protein families.

This clan contains 19 families and the total number of domains in the clan is 75226. The clan was built by A Bateman.

Literature references

  1. Ishitani R, Nureki O, Fukai S, Kijimoto T, Nameki N, Watanabe M, Kondo H, Sekine M, Okada N, Nishimura S, Yokoyama S; , J Mol Biol 2002;318:665-677.: Crystal structure of archaeosine tRNA-guanine transglycosylase. PUBMED:12054814 EPMC:12054814
  2. Iyer LM, Burroughs AM, Aravind L; , Bioinformatics. 2005; [Epub ahead of print]DR SCOP; 88697;: The ASCH superfamily: novel domains with a fold related to the PUA domain and a potential role in RNA metabolism. PUBMED:16322048 EPMC:16322048


This clan contains the following 19 member families:

ASCH DUF2584 DUF365 DUF3850 EVE LON_substr_bdg Methyltranf_PUA PrgU PUA PUA_2 PUA_3 PUA_4 RE_AspBHI_N SAD_SRA SRA TruB-C_2 TruB_C UPF0113 YTH

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
LON_substr_bdg (PF02190) 17964 (23.9%) View
PUA (PF01472) 11510 (15.3%) View
YTH (PF04146) 8725 (11.6%) View
PUA_4 (PF20260) 7290 (9.7%) View
PUA_2 (PF14306) 4769 (6.3%) View
EVE (PF01878) 4731 (6.3%) View
SAD_SRA (PF02182) 4643 (6.2%) View
PUA_3 (PF17785) 4079 (5.4%) View
ASCH (PF04266) 3997 (5.3%) View
TruB-C_2 (PF09157) 2112 (2.8%) View
UPF0113 (PF03657) 1734 (2.3%) View
Methyltranf_PUA (PF13636) 1644 (2.2%) View
TruB_C (PF09142) 1386 (1.8%) View
DUF3850 (PF12961) 272 (0.4%) View
DUF2584 (PF10763) 179 (0.2%) View
RE_AspBHI_N (PF18062) 114 (0.2%) View
SRA (PF18491) 59 (0.1%) View
DUF365 (PF04033) 16 (0.0%) View
PrgU (PF09627) 2 (0.0%) View
Total: 19 Total: 75226 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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