Summary
PUA/ASCH superfamily
This clan consists of the RNA binding PUA domain and ASCH domain. It also contains uncharacterised protein families.
This clan contains 19 families and the total number of domains in the clan is 75226. The clan was built by A Bateman.
Literature references
- Ishitani R, Nureki O, Fukai S, Kijimoto T, Nameki N, Watanabe M, Kondo H, Sekine M, Okada N, Nishimura S, Yokoyama S; , J Mol Biol 2002;318:665-677.: Crystal structure of archaeosine tRNA-guanine transglycosylase. PUBMED:12054814 EPMC:12054814
- Iyer LM, Burroughs AM, Aravind L; , Bioinformatics. 2005; [Epub ahead of print]DR SCOP; 88697;: The ASCH superfamily: novel domains with a fold related to the PUA domain and a potential role in RNA metabolism. PUBMED:16322048 EPMC:16322048
Members
This clan contains the following 19 member families:
ASCH DUF2584 DUF365 DUF3850 EVE LON_substr_bdg Methyltranf_PUA PrgU PUA PUA_2 PUA_3 PUA_4 RE_AspBHI_N SAD_SRA SRA TruB-C_2 TruB_C UPF0113 YTHDomain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
LON_substr_bdg (PF02190) | 17964 (23.9%) | View |
PUA (PF01472) | 11510 (15.3%) | View |
YTH (PF04146) | 8725 (11.6%) | View |
PUA_4 (PF20260) | 7290 (9.7%) | View |
PUA_2 (PF14306) | 4769 (6.3%) | View |
EVE (PF01878) | 4731 (6.3%) | View |
SAD_SRA (PF02182) | 4643 (6.2%) | View |
PUA_3 (PF17785) | 4079 (5.4%) | View |
ASCH (PF04266) | 3997 (5.3%) | View |
TruB-C_2 (PF09157) | 2112 (2.8%) | View |
UPF0113 (PF03657) | 1734 (2.3%) | View |
Methyltranf_PUA (PF13636) | 1644 (2.2%) | View |
TruB_C (PF09142) | 1386 (1.8%) | View |
DUF3850 (PF12961) | 272 (0.4%) | View |
DUF2584 (PF10763) | 179 (0.2%) | View |
RE_AspBHI_N (PF18062) | 114 (0.2%) | View |
SRA (PF18491) | 59 (0.1%) | View |
DUF365 (PF04033) | 16 (0.0%) | View |
PrgU (PF09627) | 2 (0.0%) | View |
Total: 19 | Total: 75226 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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