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53  structures 7558  species 0  interactions 32845  sequences 353  architectures

Clan: Rhomboid-like (CL0207)


Integral membrane protein / protease Add an annotation

This clan contains proteins from both bacteria and eukaryotes. The Rhomboid protein is an intramembrane serine protease which is involved in epidermal growth factor (EGF)-dependent signalling pathways [1]. The DER1 family is involved in degradation of misfolded ER proteins [2].

This clan contains 4 families and the total number of domains in the clan is 32845. The clan was built by J Mistry.

Literature references

  1. Koonin EV, Makarova KS, Rogozin IB, Davidovic L, Letellier MC, Pellegrini L; , Genome Biol 2003;4:R19.: The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers. PUBMED:12620104 EPMC:12620104
  2. Knop M, Finger A, Braun T, Hellmuth K, Wolf DH; , EMBO J 1996;15:753-763.: Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast. PUBMED:8631297 EPMC:8631297


This clan contains the following 4 member families:

DER1 DUF1751 Rhomboid Rhomboid_2

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Rhomboid (PF01694) 26179 (79.7%) View
DER1 (PF04511) 4329 (13.2%) View
DUF1751 (PF08551) 1746 (5.3%) View
Rhomboid_2 (PF20401) 591 (1.8%) View
Total: 4 Total: 32845 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...