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604  structures 2287  species 0  interactions 70035  sequences 1220  architectures

Clan: UBC (CL0208)


Ubiquitin conjugating enzyme like superfamily Add an annotation

This superfamily includes a diverse set of proteins that bind to ubiquitin [1].

This clan contains 14 families and the total number of domains in the clan is 70035. The clan was built by A Bateman.

Literature references

  1. Andersen KM, Hofmann K, Hartmann-Petersen R; , Essays Biochem 2005;41:49-67.: Ubiquitin-binding proteins: similar, but different. PUBMED:16250897 EPMC:16250897


This clan contains the following 14 member families:

E2-ntca FANCL_d1 FANCL_d2 FANCL_d3 Knl1_RWD_C Prok-E2_A Prok-E2_B Prok-E2_C Prok-E2_D Prok-E2_E RWD UEV UFC1 UQ_con

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
UQ_con (PF00179) 52610 (75.1%) View
RWD (PF05773) 9850 (14.1%) View
UEV (PF05743) 2588 (3.7%) View
FANCL_d3 (PF18891) 996 (1.4%) View
Knl1_RWD_C (PF18210) 968 (1.4%) View
FANCL_d2 (PF18890) 852 (1.2%) View
UFC1 (PF08694) 840 (1.2%) View
FANCL_d1 (PF09765) 500 (0.7%) View
Prok-E2_D (PF14460) 346 (0.5%) View
Prok-E2_E (PF14462) 156 (0.2%) View
Prok-E2_A (PF14457) 151 (0.2%) View
Prok-E2_B (PF14461) 142 (0.2%) View
E2-ntca (PF20298) 19 (0.0%) View
Prok-E2_C (PF14459) 17 (0.0%) View
Total: 14 Total: 70035 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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