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1294  structures 7575  species 0  interactions 433471  sequences 4574  architectures

Clan: RRM (CL0221)


RRM-like clan Add an annotation

This clan contains families that are related to the RNA recognition motif domains. However, not all these families are RNA binding.

This clan contains 33 families and the total number of domains in the clan is 433471. The clan was built by A Bateman.


This clan contains the following 33 member families:

BRAP2 Calcipressin DbpA DUF1743 DUF1866 DUF4523 GlcNAc-1_reg GUCT MARF1_RRM1 Nup35_RRM Nup35_RRM_2 PHM7_cyt Ret2_MD RL RNA_bind RRM_1 RRM_2 RRM_3 RRM_5 RRM_7 RRM_8 RRM_9 RRM_occluded RRM_Rrp7 SET_assoc Smg4_UPF3 Spo7_2_N Tap-RNA_bind Transposase_22 U1snRNP70_N xRRM XS YlmH_RBD

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RRM_1 (PF00076) 370166 (85.4%) View
PHM7_cyt (PF14703) 9729 (2.2%) View
RRM_5 (PF13893) 7883 (1.8%) View
DbpA (PF03880) 6889 (1.6%) View
RRM_8 (PF11835) 5211 (1.2%) View
RRM_7 (PF16367) 3440 (0.8%) View
RRM_2 (PF04059) 3048 (0.7%) View
Smg4_UPF3 (PF03467) 2522 (0.6%) View
XS (PF03468) 2275 (0.5%) View
Calcipressin (PF04847) 2227 (0.5%) View
BRAP2 (PF07576) 1968 (0.5%) View
YlmH_RBD (PF17774) 1918 (0.4%) View
Transposase_22 (PF02994) 1873 (0.4%) View
U1snRNP70_N (PF12220) 1701 (0.4%) View
RRM_3 (PF08777) 1566 (0.4%) View
DUF1866 (PF08952) 1551 (0.4%) View
GUCT (PF08152) 1518 (0.4%) View
Pfam family Num. domains Alignment
Nup35_RRM (PF05172) 1227 (0.3%) View
Tap-RNA_bind (PF09162) 1120 (0.3%) View
RRM_Rrp7 (PF17799) 917 (0.2%) View
RNA_bind (PF08675) 678 (0.2%) View
MARF1_RRM1 (PF11608) 649 (0.1%) View
SET_assoc (PF11767) 589 (0.1%) View
RRM_occluded (PF16842) 518 (0.1%) View
GlcNAc-1_reg (PF18440) 499 (0.1%) View
Nup35_RRM_2 (PF14605) 376 (0.1%) View
RL (PF17797) 336 (0.1%) View
DUF1743 (PF08489) 335 (0.1%) View
Spo7_2_N (PF15407) 266 (0.1%) View
xRRM (PF19977) 166 (0.0%) View
RRM_9 (PF18444) 149 (0.0%) View
DUF4523 (PF15023) 141 (0.0%) View
Ret2_MD (PF18528) 20 (0.0%) View
Total: 33 Total: 433471 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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