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623  structures 2959  species 0  interactions 325503  sequences 7696  architectures

Clan: RING (CL0229)


Ring-finger/U-box superfamily Add an annotation

This clan includes the Ring zinc finger domains as well as the U-box domain that appears to have lost the zinc coordinating cysteine residues [1].

This clan contains 44 families and the total number of domains in the clan is 325503. The clan was built by A Bateman.

Literature references

  1. Aravind L, Koonin EV; , Curr Biol 2000;10:132-134.: The U box is a modified RING finger - a common domain in ubiquitination. PUBMED:10704423 EPMC:10704423


This clan contains the following 44 member families:

Baculo_IE-1 Baculo_RING DUF1644 FANCL_C IBR Prok-RING_1 Prok-RING_2 Prok-RING_4 RINGv Rtf2 T3SS_NleG U-box UPF1_Zn_bind VATC zf-ANAPC11 zf-C3H2C3 zf-C3HC4 zf-C3HC4_2 zf-C3HC4_3 zf-C3HC4_4 zf-C3HC4_5 zf-MIZ zf-NOSIP zf-Nse zf-P11 zf-rbx1 zf-RING-like zf-RING_10 zf-RING_11 zf-RING_12 zf-RING_13 zf-RING_14 zf-RING_15 zf-RING_16 zf-RING_2 zf-RING_4 zf-RING_5 zf-RING_6 zf-RING_9 zf-RING_UBOX zf-UBP zf-UBP_var zf-UDP zinc_ribbon_16

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
zf-RING_2 (PF13639) 80991 (24.9%) View
zf-C3HC4_3 (PF13920) 42345 (13.0%) View
zf-C3HC4 (PF00097) 34770 (10.7%) View
IBR (PF01485) 27333 (8.4%) View
zf-C3HC4_2 (PF13923) 24199 (7.4%) View
U-box (PF04564) 19575 (6.0%) View
zf-UBP (PF02148) 14293 (4.4%) View
zf-C3HC4_4 (PF15227) 14272 (4.4%) View
RINGv (PF12906) 14205 (4.4%) View
zf-MIZ (PF02891) 6555 (2.0%) View
zf-rbx1 (PF12678) 4857 (1.5%) View
zf-RING_5 (PF14634) 4471 (1.4%) View
zf-RING_4 (PF14570) 3816 (1.2%) View
zf-RING_11 (PF17123) 3590 (1.1%) View
zf-RING_9 (PF13901) 3294 (1.0%) View
zf-UDP (PF14569) 2387 (0.7%) View
Rtf2 (PF04641) 2312 (0.7%) View
zf-UBP_var (PF17807) 2220 (0.7%) View
UPF1_Zn_bind (PF09416) 1943 (0.6%) View
Prok-RING_4 (PF14447) 1938 (0.6%) View
DUF1644 (PF07800) 1842 (0.6%) View
zf-ANAPC11 (PF12861) 1654 (0.5%) View
zf-Nse (PF11789) 1588 (0.5%) View
Pfam family Num. domains Alignment
zf-RING_16 (PF17120) 1368 (0.4%) View
zf-RING-like (PF08746) 1259 (0.4%) View
zinc_ribbon_16 (PF17034) 1217 (0.4%) View
zf-C3HC4_5 (PF17121) 1191 (0.4%) View
zf-NOSIP (PF15906) 1187 (0.4%) View
FANCL_C (PF11793) 1029 (0.3%) View
VATC (PF18716) 683 (0.2%) View
zf-RING_14 (PF17978) 612 (0.2%) View
zf-C3H2C3 (PF17122) 592 (0.2%) View
zf-RING_12 (PF17976) 540 (0.2%) View
zf-RING_10 (PF16685) 462 (0.1%) View
zf-RING_6 (PF14835) 388 (0.1%) View
zf-RING_15 (PF16744) 321 (0.1%) View
Prok-RING_1 (PF14446) 123 (0.0%) View
T3SS_NleG (PF06416) 21 (0.0%) View
Baculo_RING (PF05883) 19 (0.0%) View
zf-P11 (PF03854) 14 (0.0%) View
Prok-RING_2 (PF14445) 13 (0.0%) View
Baculo_IE-1 (PF05290) 12 (0.0%) View
zf-RING_13 (PF17977) 2 (0.0%) View
zf-RING_UBOX (PF13445) 0 (0.0%) View
Total: 44 Total: 325503
No alignment ℹ

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...