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1581  structures 9150  species 0  interactions 114209  sequences 1634  architectures

Clan: HD_PDEase (CL0237)


HD/PDEase superfamily Add an annotation

This clan includes a range of phosphohydrolase enzymes with a common helical fold.

This clan contains 13 families and the total number of domains in the clan is 114209. The clan was built by A Bateman.


This clan contains the following 13 member families:

DUF4202 HD HD_3 HD_4 HD_5 HD_6 HDOD MIOX PDEase_I SidE_PDE TraI_2 tRNA_NucTran2_2 YfbR-like

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HD (PF01966) 51616 (45.2%) View
PDEase_I (PF00233) 19591 (17.2%) View
HD_4 (PF13328) 13635 (11.9%) View
HDOD (PF08668) 8071 (7.1%) View
HD_5 (PF13487) 7901 (6.9%) View
HD_3 (PF13023) 4471 (3.9%) View
MIOX (PF05153) 2374 (2.1%) View
tRNA_NucTran2_2 (PF13735) 1853 (1.6%) View
HD_6 (PF18019) 1850 (1.6%) View
YfbR-like (PF12917) 1443 (1.3%) View
DUF4202 (PF13875) 894 (0.8%) View
TraI_2 (PF07514) 467 (0.4%) View
SidE_PDE (PF12252) 43 (0.0%) View
Total: 13 Total: 114209 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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