Summary
PFK-like superfamily
This clan includes two SCOP superfamilies. Strong similarities between NAD kinases, DAG kinase, sphingosine kinase and PFK have previously been shown[1].
This clan contains 4 families and the total number of domains in the clan is 62978. The clan was built by A Bateman.
Literature references
- Labesse G, Douguet D, Assairi L, Gilles AM; , Trends Biochem Sci. 2002;27:273-275.: Diacylglyceride kinases, sphingosine kinases and NAD kinases: distant relatives of 6-phosphofructokinases. PUBMED:12069781 EPMC:12069781
Members
This clan contains the following 4 member families:
DAGK_cat NAD_kinase PFK Pfk_NExternal database links
SCOP: | 53784 111331 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
DAGK_cat (PF00781) | 27760 (44.1%) | View |
PFK (PF00365) | 21644 (34.4%) | View |
NAD_kinase (PF01513) | 13488 (21.4%) | View |
Pfk_N (PF18468) | 86 (0.1%) | View |
Total: 4 | Total: 62978 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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